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Showing 1 to 6 of 6 entries
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Micropatterned nanostructures: a bioengineered approach to mass-produce functional myocardial grafts.

Nanotechnology

Serpooshan V, Mahmoudi M.
PMID: 25611345
Nanotechnology. 2015 Feb 13;26(6):060501. doi: 10.1088/0957-4484/26/6/060501. Epub 2015 Jan 22.

Cell-based therapies are a recently established path for treating a wide range of human disease. Tissue engineering of contractile heart muscle for replacement therapy is among the most exciting and important of these efforts. However, current in vitro techniques...

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.

PLoS computational biology

Mayourian J, Savizky RM, Sobie EA, Costa KD.
PMID: 27454812
PLoS Comput Biol. 2016 Jul 25;12(7):e1005014. doi: 10.1371/journal.pcbi.1005014. eCollection 2016 Jul.

Human mesenchymal stem cell (hMSC) delivery has demonstrated promise in preclinical and clinical trials for myocardial infarction therapy; however, broad acceptance is hindered by limited understanding of hMSC-human cardiomyocyte (hCM) interactions. To better understand the electrophysiological consequences of direct...

Simulating T-wave parameters of local extracellular electrograms with a whole-heart bidomain reaction-diffusion model: Size matters!.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Potse M, Coronel R, Opthof T, Vinet A.
PMID: 18003549
Annu Int Conf IEEE Eng Med Biol Soc. 2007;2007:6644-7. doi: 10.1109/IEMBS.2007.4353883.

As a measure of local repolarization time (T(R)), the instant of maximum slope (T(up)) of the T wave in the local unipolar electrogram is commonly used. Measurement of T(up) can be difficult, especially in positive T waves. These difficulties...

Modeling inherited cardiac disease using patient specific iPS cell derived cardiomyocytes.

Nihon rinsho. Japanese journal of clinical medicine

Ito M, Naito A, Komuro I.
PMID: 30458089
Nihon Rinsho. 2015 Jun;73:411-5.

No abstract available.

9th Ascona International Workshop on Cardiomyocyte Biology.

Biochimica et biophysica acta. Molecular cell research

Brink M, Zuppinger C.
PMID: 31837983
Biochim Biophys Acta Mol Cell Res. 2020 Mar;1867(3):118618. doi: 10.1016/j.bbamcr.2019.118618. Epub 2019 Dec 12.

No abstract available.

Towards chamber specific heart-on-a-chip for drug testing applications.

Advanced drug delivery reviews

Zhao Y, Rafatian N, Wang EY, Wu Q, Lai BFL, Lu RX, Savoji H, Radisic M.
PMID: 31917972
Adv Drug Deliv Rev. 2020;165:60-76. doi: 10.1016/j.addr.2019.12.002. Epub 2020 Jan 07.

Modeling of human organs has long been a task for scientists in order to lower the costs of therapeutic development and understand the pathological onset of human disease. For decades, despite marked differences in genetics and etiology, animal models...

Showing 1 to 6 of 6 entries