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Andreou I, Sun X, Stone PH, et al. miRNAs in atherosclerotic plaque initiation, progression, and rupture. Trends Mol Med. 2015;21(5):307-18doi: 10.1016/j.molmed.2015.02.003.
Andreou, I., Sun, X., Stone, P. H., Edelman, E. R., & Feinberg, M. W. (2015). miRNAs in atherosclerotic plaque initiation, progression, and rupture. Trends in molecular medicine, 21(5), 307-18. https://doi.org/10.1016/j.molmed.2015.02.003
Andreou, Ioannis, et al. "miRNAs in atherosclerotic plaque initiation, progression, and rupture." Trends in molecular medicine vol. 21,5 (2015): 307-18. doi: https://doi.org/10.1016/j.molmed.2015.02.003
Andreou I, Sun X, Stone PH, Edelman ER, Feinberg MW. miRNAs in atherosclerotic plaque initiation, progression, and rupture. Trends Mol Med. 2015 May;21(5):307-18. doi: 10.1016/j.molmed.2015.02.003. Epub 2015 Mar 11. PMID: 25771097; PMCID: PMC4424146.
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Trends Mol Med. 2015 May;21(5):307-18. doi: 10.1016/j.molmed.2015.02.003. Epub 2015 Mar 11.

miRNAs in atherosclerotic plaque initiation, progression, and rupture.

Trends in molecular medicine

Ioannis Andreou, Xinghui Sun, Peter H Stone, Elazer R Edelman, Mark W Feinberg

Affiliations

  1. Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  2. Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  3. Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 25771097 PMCID: PMC4424146 DOI: 10.1016/j.molmed.2015.02.003

Abstract

Atherosclerosis is a chronic immune-inflammatory disorder that integrates multiple cell types and a diverse set of inflammatory mediators. miRNAs are emerging as important post-transcriptional regulators of gene expression in most, if not all, vertebrate cells, and constitute central players in many physiological and pathological processes. Rapidly accumulating experimental studies reveal their key role in cellular and molecular processes related to the development of atherosclerosis. We review current evidence for the involvement of miRNAs in early atherosclerotic lesion formation and in plaque rupture and erosion. We conclude with a perspective on the clinical relevance, therapeutic opportunities, and future challenges of miRNA biology in understanding the pathogenesis of this complex disease.

Copyright © 2015 Elsevier Ltd. All rights reserved.

Keywords: atherosclerosis; inflammation; miRNAs; shear stress; vulnerable plaque

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