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Wang J, Xiao Y, Lin K, et al. Pediatric severe pseudomembranous enteritis treated with fecal microbiota transplantation in a 13-month-old infant. Biomed Rep. 2014;3(2):173-175doi: 10.3892/br.2014.403.
Wang, J., Xiao, Y., Lin, K., Song, F., Ge, T., & Zhang, T. (2015). Pediatric severe pseudomembranous enteritis treated with fecal microbiota transplantation in a 13-month-old infant. Biomedical reports, 3(2), 173-175. https://doi.org/10.3892/br.2014.403
Wang, Jiayi, et al. "Pediatric severe pseudomembranous enteritis treated with fecal microbiota transplantation in a 13-month-old infant." Biomedical reports vol. 3,2 (2015): 173-175. doi: https://doi.org/10.3892/br.2014.403
Wang J, Xiao Y, Lin K, Song F, Ge T, Zhang T. Pediatric severe pseudomembranous enteritis treated with fecal microbiota transplantation in a 13-month-old infant. Biomed Rep. 2015 Mar;3(2):173-175. doi: 10.3892/br.2014.403. Epub 2014 Dec 15. PMID: 25798243; PMCID: PMC4360647.
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Biomed Rep. 2015 Mar;3(2):173-175. doi: 10.3892/br.2014.403. Epub 2014 Dec 15.

Pediatric severe pseudomembranous enteritis treated with fecal microbiota transplantation in a 13-month-old infant.

Biomedical reports

Jiayi Wang, Yongmei Xiao, Kai Lin, Feifei Song, Ting Ge, Ting Zhang

Affiliations

  1. Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai, P.R. China ; Department of Anesthesiology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.
  2. Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai, P.R. China.

PMID: 25798243 PMCID: PMC4360647 DOI: 10.3892/br.2014.403

Abstract

Fecal microbiota transplantation (FMT) is a procedure used to restore the intestinal microbiota of a diseased individual using indigenous intestinal microorganisms from a healthy donor. The current case report presents the first case of a 13-month-old male with severe pseudomembranous enteritis (PME) treated with FMT. The infant was admitted to Shanghai Children's Hospital with a 2-month history of diarrhea, and a 1.5-month history of retractable edema, hypoalbuminemia, electrolyte disturbance and malnutrition. Besides necessary nutritional support, the patient was treated twice with oral metronidazole combined with or without vancomycin. Diarrhea was partially remitted. However, the infant had bloody or dark-green feces, and a distended abdomen. On day 96 from the initiation of the disease, a single FMT via a nasal jejuna feeding tube was performed. From day 2 until 4 months post-FMT, the patient presented with no diarrhea, normal feces and a satisfactory weight. To the best of our knowledge, this is the first pediatric PME treated with FMT. The current data show that FMT is an efficient choice for recurrent

Keywords: children; clostridium difficile infection; fecal microbiota transplantation; pseudomembranous enteritis

References

  1. Am J Gastroenterol. 2013 Apr;108(4):478-98; quiz 499 - PubMed
  2. Am J Gastroenterol. 2012 Jul;107(7):1079-87 - PubMed
  3. N Engl J Med. 2013 Jan 31;368(5):407-15 - PubMed
  4. Pediatrics. 2010 Jul;126(1):e239-42 - PubMed
  5. JAMA Pediatr. 2013 Jun;167(6):567-73 - PubMed
  6. J Clin Gastroenterol. 2004 Jul;38(6):475-83 - PubMed
  7. Infect Control Hosp Epidemiol. 2010 May;31(5):431-55 - PubMed

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