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Yu J, Xiang M, Wu H, et al. Ephrin A2 protein expression in the regeneration and plasticity of cochlear hair cells in chicken following kanamycin ototoxicity. Neural Regen Res. 2012;7(9):714-8doi: 10.3969/j.issn.1673-5374.2012.09.013.
Yu, J., Xiang, M., Wu, H., & Shen, C. (2012). Ephrin A2 protein expression in the regeneration and plasticity of cochlear hair cells in chicken following kanamycin ototoxicity. Neural regeneration research, 7(9), 714-8. https://doi.org/10.3969/j.issn.1673-5374.2012.09.013
Yu, Jia, et al. "Ephrin A2 protein expression in the regeneration and plasticity of cochlear hair cells in chicken following kanamycin ototoxicity." Neural regeneration research vol. 7,9 (2012): 714-8. doi: https://doi.org/10.3969/j.issn.1673-5374.2012.09.013
Yu J, Xiang M, Wu H, Shen C. Ephrin A2 protein expression in the regeneration and plasticity of cochlear hair cells in chicken following kanamycin ototoxicity. Neural Regen Res. 2012 Mar 25;7(9):714-8. doi: 10.3969/j.issn.1673-5374.2012.09.013. PMID: 25745469; PMCID: PMC4347014.
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Neural Regen Res. 2012 Mar 25;7(9):714-8. doi: 10.3969/j.issn.1673-5374.2012.09.013.

Ephrin A2 protein expression in the regeneration and plasticity of cochlear hair cells in chicken following kanamycin ototoxicity.

Neural regeneration research

Jia Yu, Mingliang Xiang, Hao Wu, Chenling Shen

Affiliations

  1. Department of OtlaryngoIogy & Head and Neck Surgery of Xinhua Hospital, Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

PMID: 25745469 PMCID: PMC4347014 DOI: 10.3969/j.issn.1673-5374.2012.09.013

Abstract

The results from this study showed that the thresholds of brainstem auditory-evoked potentials peak following 10 successive days of intramuscular injection of Roman chickens with kanamycin, starting 3 days after birth. Fluorescence immunohistochemistry analysis revealed few ganglion cells positively labeled for Ephrin A2 in the cochlea of experimental chickens from 2 days before until 7 days after the last kanamycin injection. The number of Ephrin A2-positive ganglion cell bodies was increased at 15 days after the last injection and was similar to that in normal chickens at 30 days following the cessation of kanamycin treatment. These experimental findings indicate that Ephrin A2 protein expression in the acoustic ganglia is synchronized with the connection damage and regeneration of cochlear hair cells after kanamycin exposure. Ephrin A2 may play an important role in the regeneration and plasticity of cochlear hair cells in the chick cochlea following kanamycin ototoxicity.

Keywords: Ephrin A2; cochlear hair cells; inner ear; neural regeneration; plasticity; reinnervation

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