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ACS Nano. 2015 Apr 28;9(4):3418-20. doi: 10.1021/acsnano.5b01723. Epub 2015 Apr 16.

Mimicking membrane-related biological events by DNA origami nanotechnology.

ACS nano

Yuki Suzuki, Masayuki Endo, Hiroshi Sugiyama

Affiliations

  1. †Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
  2. §CREST, Japan Science and Technology Agency (JST), Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan.
  3. ‡Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan.

PMID: 25880224 DOI: 10.1021/acsnano.5b01723

Abstract

One of the potential applications of DNA nanotechnology is the construction of two- or three-dimensional nanostructures that mimic the function of existing biological molecules. In this issue of ACS Nano, Kocabey et al. demonstrate that lipid-bilayer-anchored DNA origami structures can be assembled into prescribed superstructures in a programmed manner. The reported DNA-based artificial system can mimic the dynamic assembly of membrane-associated protein clusters that play an essential role in deformation of cellular membranes.

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