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Showing 1 to 12 of 293 entries
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Numerical studies of electrokinetic control of DNA concentration in a closed-end microchannel.

Electrophoresis

Daghighi Y, Li D.
PMID: 20191548
Electrophoresis. 2010 Mar;31(5):868-78. doi: 10.1002/elps.200900447.

A major challenge in lab-on-a-chip devices is how to concentrate sample molecules from a dilute solution, which is critical to the effectiveness and the detection limit of on-chip bio-chemical reactions. A numerical study of sample concentration control by electrokinetic...

Well-less capillary array electrophoresis chip using hydrophilic sample bridges.

Analytical chemistry

Kim YH, Yang I, Park SR.
PMID: 17927141
Anal Chem. 2007 Dec 01;79(23):9205-10. doi: 10.1021/ac071115p. Epub 2007 Oct 10.

An innovative sample introduction method that facilitates extreme simplification of the layout of a capillary array electrophoresis (CAE) chip is described. Multiple samples were directly injected onto CAE channels from sample loaders using hydrophilic sample bridges, thus obviating auxiliary...

[How a long linear molecule can be straightened on a support].

Biofizika

Namiot VA.
PMID: 19334628
Biofizika. 2009 Jan-Feb;54(1):13-5.

A relatively simple means is proposed for fastening a macromolecule such as DNA in a straight line on a dielectric support (which is essential for "fast reading" of sequences by physical methods). A randomly coiled molecule in solution can...

X-ray crystallography and the elucidation of the structure of DNA.

AJR. American journal of roentgenology

McGregor HC, Gunderman RB.
PMID: 21606255
AJR Am J Roentgenol. 2011 Jun;196(6):W689-92. doi: 10.2214/AJR.10.5479.

OBJECTIVE: Since their discovery by Roentgen in 1895, x-rays have contributed to some of the most important advances in science. X-ray crystallography is an imaging technique that uses x-ray diffraction to evaluate the molecular structure of a crystalline solid....

Consequences of local inter-strand dehybridization for large-amplitude bending fluctuations of double-stranded DNA.

The Journal of chemical physics

Sivak DA, Geissler PL.
PMID: 22299918
J Chem Phys. 2012 Jan 28;136(4):045102. doi: 10.1063/1.3679654.

The wormlike chain model of DNA bending accurately reproduces single-molecule force-extension profiles of long (kilobase) chains. These bending statistics over large scales do not, however, establish a unique microscopic model for elasticity at the 1-10 basepair (bp) scale, which...

I-motif-programmed functionalization of DNA nanocircles.

Journal of the American Chemical Society

Li T, Famulok M.
PMID: 23312021
J Am Chem Soc. 2013 Jan 30;135(4):1593-9. doi: 10.1021/ja3118224. Epub 2013 Jan 22.

The folding of various intra- and intermolecular i-motif DNAs is systematically studied to expand the toolbox for the control of mechanical operations in DNA nanoarchitectures. We analyzed i-motif DNAs with two C-tracts under acidic conditions by gel electrophoresis, circular...

Programmable imaging amplification via nanoparticle-initiated DNA polymerization.

Small (Weinheim an der Bergstrasse, Germany)

Chen N, Li S, Battig MR, Wang Y.
PMID: 23813897
Small. 2013 Dec 09;9(23):3944-9. doi: 10.1002/smll.201300806. Epub 2013 Jul 01.

No abstract available.

Chemical biology: DNA's new alphabet.

Nature

Kwok R.
PMID: 23172197
Nature. 2012 Nov 22;491(7425):516-8. doi: 10.1038/491516a.

No abstract available.

[A persistent model of the reptation movement of a DNA molecule].

Biofizika

Nemtsov VB, Kamliuk AN, Shirko AV.
PMID: 20429276
Biofizika. 2010 Mar-Apr;55(2):233-8.

By using a persistent model of the movement of a DNA molecule, the penetration of the DNA molecule into a cell has been described. The method enables one to estimate the time and the rate of the passage of...

Collapse of DNA in ac electric fields.

Physical review letters

Zhou C, Reisner WW, Staunton RJ, Ashan A, Austin RH, Riehn R.
PMID: 21770604
Phys Rev Lett. 2011 Jun 17;106(24):248103. doi: 10.1103/PhysRevLett.106.248103. Epub 2011 Jun 16.

We report that double-stranded DNA collapses in the presence of ac electric fields at frequencies of a few hundred Hertz, and does not stretch as commonly assumed. In particular, we show that confinement-stretched DNA can collapse to about one...

Pattern transformation with DNA circuits.

Nature chemistry

Chirieleison SM, Allen PB, Simpson ZB, Ellington AD, Chen X.
PMID: 24256862
Nat Chem. 2013 Dec;5(12):1000-5. doi: 10.1038/nchem.1764. Epub 2013 Sep 29.

Readily programmable chemical networks are important tools as the scope of chemistry expands from individual molecules to larger molecular systems. Although many complex systems are constructed using conventional organic and inorganic chemistry, the programmability of biological molecules such as...

High throughput sequencing methods and analysis for microbiome research.

Journal of microbiological methods

Di Bella JM, Bao Y, Gloor GB, Burton JP, Reid G.
PMID: 24029734
J Microbiol Methods. 2013 Dec;95(3):401-14. doi: 10.1016/j.mimet.2013.08.011. Epub 2013 Sep 09.

High-throughput sequencing technology is rapidly improving in quality, speed and cost. It is therefore becoming more widely used to study whole communities of prokaryotes in many niches. This review discusses these techniques, including nucleic acid extraction from different environments,...

Showing 1 to 12 of 293 entries