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Makatsori M, Senna G, Pitsios C, et al. Prospective adherence to specific immunotherapy in Europe (PASTE) survey protocol. Clin Transl Allergy. 2015;5:17doi: 10.1186/s13601-015-0060-0.
Makatsori, M., Senna, G., Pitsios, C., Lleonart, R., Klimek, L., Nunes, C., Rukhadze, M., Rogala, B., Gawlik, R., Panzner, P., Pfaar, O., & Calderon, M. (2015). Prospective adherence to specific immunotherapy in Europe (PASTE) survey protocol. Clinical and translational allergy, 517. https://doi.org/10.1186/s13601-015-0060-0
Makatsori, Melina, et al. "Prospective adherence to specific immunotherapy in Europe (PASTE) survey protocol." Clinical and translational allergy vol. 5 (2015): 17. doi: https://doi.org/10.1186/s13601-015-0060-0
Makatsori M, Senna G, Pitsios C, Lleonart R, Klimek L, Nunes C, Rukhadze M, Rogala B, Gawlik R, Panzner P, Pfaar O, Calderon M. Prospective adherence to specific immunotherapy in Europe (PASTE) survey protocol. Clin Transl Allergy. 2015 Apr 27;5:17. doi: 10.1186/s13601-015-0060-0. eCollection 2015. PMID: 25918637; PMCID: PMC4410463.
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Clin Transl Allergy. 2015 Apr 27;5:17. doi: 10.1186/s13601-015-0060-0. eCollection 2015.

Prospective adherence to specific immunotherapy in Europe (PASTE) survey protocol.

Clinical and translational allergy

Melina Makatsori, Gianenrico Senna, Constantinos Pitsios, Ramon Lleonart, Ludger Klimek, Carlos Nunes, Maia Rukhadze, Barbara Rogala, Radoslaw Gawlik, Petr Panzner, Oliver Pfaar, Moises Calderon

Affiliations

  1. Royal Brompton and Harefield NHS Trust, London, UK ; Imperial College London, National Heart and Lung Institute, London, UK.
  2. Allergy Department, Azienda Universitaria-Ospedaliera Integrata, Verona, Italy.
  3. Private Allergy Clinic, Athens, Greece.
  4. Allergy Department, University Hospital of Bellvitge, Barcelona, Spain.
  5. Center for Rhinology and Allergology, Wiesbaden, Germany.
  6. Centro de Imunoalergologia do Algarve, Portimao, Portugal.
  7. Allergy & Immunology Centre, Tbilisi, Georgia.
  8. Medical University of Silesia, Allergology & Clinical Immunology, Katowice, Poland.
  9. Faculty of Medicine in Pilsen, Charles University Prague, Immunology and Allergology, Pilsen, Czech Republic.
  10. Center for Rhinology and Allergology, Wiesbaden, Germany ; Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

PMID: 25918637 PMCID: PMC4410463 DOI: 10.1186/s13601-015-0060-0

Abstract

BACKGROUND: Adherence to allergen immunotherapy is important for its effectiveness. There is currently limited data available on allergen immunotherapy adherence outside of clinical trials i.e. in real-life clinical practice. As part of a European Academy of Allergy and Clinical Immunology Immunotherapy Interest group initiative, we endeavoured to design a survey in order to prospectively evaluate adherence to subcutaneous and sublingual immunotherapy across different European countries.

METHOD/DESIGN: The inclusion criteria for this prospective, multi-country survey were set as: adults, starting clinically indicated allergen immunotherapy for respiratory allergic disorders or Hymenoptera venom allergy. An online survey was designed in order to enrol participants and assess adherence to immunotherapy. Eight countries (Czech Republic, Georgia, Germany, Greece, Italy, Poland, Portugal, Spain) were selected to reflect different parts of Europe and differences in allergens and routes of immunotherapy administration. Each country has an allocated National co-ordinator that has identified local Allergy departments willing to enrol participants in this survey. Each participant will be followed up for a total of three years. In order to assess adherence, a 4-monthly follow-up form detailing any missed doses and reasons will be completed online. In case of a participant discontinuing treatment, reasons for this will be recorded.

DISCUSSION: The use of online survey software has enabled us to make this survey a reality and reach clinicians in different countries. Forty-five centres have enrolled a total of over 1,350 participants. It is hoped that this prospective real life survey will enable us to gain a better understanding of reasons that affect adherence to subcutaneous and sublingual immunotherapy and assist in developing ways to improve this.

Keywords: Adherence; Hymenoptera venom allergy; Online register; Online survey; Respiratory allergic disorders; Subcutaneous immunotherapy; Sublingual immunotherapy

References

  1. Allergy. 2014 May;69(5):571-80 - PubMed
  2. Int Forum Allergy Rhinol. 2012 Jul-Aug;2(4):280-4 - PubMed
  3. Ann Allergy Asthma Immunol. 1999 Mar;82(3):281-6 - PubMed
  4. J Allergy Clin Immunol Pract. 2014 Mar-Apr;2(2):156-60 - PubMed
  5. Curr Opin Allergy Clin Immunol. 2014 Aug;14(4):340-6 - PubMed
  6. Pediatr Allergy Immunol. 2012 Nov;23(7):688-9 - PubMed
  7. Am J Respir Crit Care Med. 2009 Nov 1;180(9):817-22 - PubMed
  8. Ann Allergy Asthma Immunol. 2014 Jan;112(1):79-81 - PubMed
  9. Clin Exp Otorhinolaryngol. 2009 Sep;2(3):136-40 - PubMed
  10. Eur Ann Allergy Clin Immunol. 2014 Mar;46(2):87-94 - PubMed
  11. Indian J Chest Dis Allied Sci. 2010 Apr-Jun;52(2):91-5 - PubMed
  12. J Allergy Clin Immunol. 2010 Jan;125(1):131-8.e1-7 - PubMed
  13. J Allergy Clin Immunol. 2006 Apr;117(4):946-8 - PubMed
  14. J Investig Allergol Clin Immunol. 2006;16(4):218-23 - PubMed
  15. J Allergy Clin Immunol. 2004 Jun;113(6):1219-20 - PubMed
  16. Pediatr Allergy Immunol. 2007 Feb;18(1):58-62 - PubMed
  17. Eur J Public Health. 2007 Jun;17(3):278-84 - PubMed
  18. N Engl J Med. 2005 Aug 4;353(5):487-97 - PubMed
  19. J Allergy Clin Immunol. 2013 Aug;132(2):353-60.e2 - PubMed
  20. Clin Ther. 2009 Feb;31(2):321-7 - PubMed
  21. Curr Opin Allergy Clin Immunol. 2013 Dec;13(6):656-62 - PubMed
  22. Allergy. 2004 Nov;59(11):1205-10 - PubMed
  23. J Allergy Clin Immunol. 2012 Mar;129(3):717-725.e5 - PubMed
  24. Allergy. 2004 Nov;59(11):1224-8 - PubMed
  25. Int J Immunopathol Pharmacol. 2008 Apr-Jun;21(2):471-3 - PubMed
  26. Clin Exp Allergy. 2008 Oct;38(10):1659-67 - PubMed
  27. Clin Transl Allergy. 2014 Apr 29;4:15 - PubMed
  28. J Allergy Clin Immunol Pract. 2014 Mar-Apr;2(2):152-5 - PubMed
  29. Rev Alerg Mex. 1997 Mar-Apr;44(2):42-4 - PubMed
  30. J Allergy Clin Immunol. 1997 Apr;99(4):450-3 - PubMed
  31. Allergy. 2010 May;65(5):668-9 - PubMed
  32. Allergy. 2007 Aug;62(8):943-8 - PubMed
  33. Ann Allergy Asthma Immunol. 1995 Mar;74(3):241-6 - PubMed
  34. J Allergy Clin Immunol. 2008 Jan;121(1):227-32 - PubMed
  35. Ann Allergy Asthma Immunol. 2002 Apr;88(4):391-4 - PubMed
  36. Clin Exp Allergy. 2013 Jan;43(1):22-8 - PubMed
  37. Clin Exp Allergy. 2001 Sep;31(9):1392-7 - PubMed
  38. N Engl J Med. 2010 Apr 29;362(17):1553-5 - PubMed
  39. Allergy. 2009 Jan;64(1):179-86 - PubMed
  40. Ann Allergy Asthma Immunol. 1999 Apr;82(4):339-47 - PubMed
  41. Med Care. 2004 Mar;42(3):200-9 - PubMed
  42. Allergy. 2006 Feb;61(2):198-201 - PubMed
  43. J Allergy Clin Immunol. 2005 Dec;116(6):1380-1 - PubMed
  44. World Allergy Organ J. 2014 Mar 28;7(1):6 - PubMed
  45. Ann Allergy. 1993 Jun;70(6):480-2 - PubMed
  46. J Allergy Clin Immunol. 1993 Mar;91(3):734-7 - PubMed

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