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Key T, Watson CJ, Clatworthy MR, et al. The kinetics of donor HLA class I-specific antibody absorption following a combined split liver and kidney transplant. NDT Plus. 2010;3(6):579-81doi: 10.1093/ndtplus/sfq160.
Key, T., Watson, C. J., Clatworthy, M. R., O'Rourke, C. M., Goodman, R. S., Taylor, C. J., & Butler, A. J. (2010). The kinetics of donor HLA class I-specific antibody absorption following a combined split liver and kidney transplant. NDT plus, 3(6), 579-81. https://doi.org/10.1093/ndtplus/sfq160
Key, Tim, et al. "The kinetics of donor HLA class I-specific antibody absorption following a combined split liver and kidney transplant." NDT plus vol. 3,6 (2010): 579-81. doi: https://doi.org/10.1093/ndtplus/sfq160
Key T, Watson CJ, Clatworthy MR, O'Rourke CM, Goodman RS, Taylor CJ, Butler AJ. The kinetics of donor HLA class I-specific antibody absorption following a combined split liver and kidney transplant. NDT Plus. 2010 Dec;3(6):579-81. doi: 10.1093/ndtplus/sfq160. Epub 2010 Sep 06. PMID: 25949473; PMCID: PMC4421431.
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NDT Plus. 2010 Dec;3(6):579-81. doi: 10.1093/ndtplus/sfq160. Epub 2010 Sep 06.

The kinetics of donor HLA class I-specific antibody absorption following a combined split liver and kidney transplant.

NDT plus

Tim Key, Christopher J Watson, Menna R Clatworthy, Cheryl M O'Rourke, Reyna S Goodman, Craig J Taylor, Andrew J Butler

Affiliations

  1. Tissue Typing Laboratory.
  2. Department of Surgery.
  3. Division of Renal Medicine , Cambridge University Hospitals NHS Foundation Trust , Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ UK.

PMID: 25949473 PMCID: PMC4421431 DOI: 10.1093/ndtplus/sfq160

Abstract

Hyperacute rejection of a transplanted liver is rare even when the recipient has circulating donor-specific alloantibodies (DSA). There is also evidence that a transplanted liver may provide immunological protection for other organs transplanted from the same donor. We monitored the kinetics of circulating DSA in a highly sensitized recipient of a combined split liver and kidney transplant and demonstrated a reduction in antibody titres immediately after liver perfusion. The absorption of DSA was not compromised by the smaller liver mass transplanted. DSA titres remained low at 3 months post-transplant, and the recipient did not experience antibody-mediated rejection.

Keywords: HLA-specific antibody; hyperacute rejection; liver–kidney transplant

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