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Zapata JC, Salvato MS. Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man. Future Virol. 2015;10(3):233-256doi: 10.2217/fvl.15.1.
Zapata, J. C., & Salvato, M. S. (2015). Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man. Future virology, 10(3), 233-256. https://doi.org/10.2217/fvl.15.1
Zapata, Juan C, and Salvato, Maria S. "Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man." Future virology vol. 10,3 (2015): 233-256. doi: https://doi.org/10.2217/fvl.15.1
Zapata JC, Salvato MS. Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man. Future Virol. 2015 Mar 13;10(3):233-256. doi: 10.2217/fvl.15.1. PMID: 25844088; PMCID: PMC4383259.
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Future Virol. 2015 Mar 13;10(3):233-256. doi: 10.2217/fvl.15.1.

Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man.

Future virology

Juan C Zapata, Maria S Salvato

Affiliations

  1. Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

PMID: 25844088 PMCID: PMC4383259 DOI: 10.2217/fvl.15.1

Abstract

Lassa virus infection elicits distinctive changes in host gene expression and metabolism. We focus on changes in host gene expression that may be biomarkers that discriminate individual pathogens or may help to provide a prognosis for disease. In addition to assessing mRNA changes, functional studies are also needed to discriminate causes of disease from mechanisms of host resistance. Host responses that drive pathogenesis are likely to be targets for prevention or therapy. Host responses to Lassa or its related arenaviruses have been monitored in cell culture, in animal models of hemorrhagic fever, in Lassa-infected nonhuman primates and, to a limited extent, in infected human beings. Here, we describe results from those studies and discuss potential targets for reducing virus replication and mitigating disease.

Keywords: Lassa fever; hemorrhagic fever viruses; transcriptome profiling

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