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McCullough LE, Chen J, White AJ, et al. Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity. Int J Cancer Clin Res. 2015;2(1)doi: 10.23937/2378-3419/2/1/1013.
McCullough, L. E., Chen, J., White, A. J., Xu, X., Cho, Y. H., Bradshaw, P. T., Eng, S. M., Teitelbaum, S. L., Terry, M. B., Garbowski, G., Neugut, A. I., Hibshoosh, H., Santella, R. M., & Gammon, M. D. (2015). Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity. International journal of cancer and clinical research, 2(1), . https://doi.org/10.23937/2378-3419/2/1/1013
McCullough, Lauren E, et al. "Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity." International journal of cancer and clinical research vol. 2,1 (2015). doi: https://doi.org/10.23937/2378-3419/2/1/1013
McCullough LE, Chen J, White AJ, Xu X, Cho YH, Bradshaw PT, Eng SM, Teitelbaum SL, Terry MB, Garbowski G, Neugut AI, Hibshoosh H, Santella RM, Gammon MD. Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity. Int J Cancer Clin Res. 2015;2(1). doi: 10.23937/2378-3419/2/1/1013. PMID: 26005715; PMCID: PMC4440485.
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Int J Cancer Clin Res. 2015;2(1). doi: 10.23937/2378-3419/2/1/1013.

Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity.

International journal of cancer and clinical research

Lauren E McCullough, Jia Chen, Alexandra J White, Xinran Xu, Yoon Hee Cho, Patrick T Bradshaw, Sybil M Eng, Susan L Teitelbaum, Mary Beth Terry, Gail Garbowski, Alfred I Neugut, Hanina Hibshoosh, Regina M Santella, Marilie D Gammon

Affiliations

  1. Department of Epidemiology, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA.
  2. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai; New York, NY, 10016, USA ; Department of Pediatrics, Icahn School of Medicine at Mount Sinai; New York, NY, 10016, USA ; Department of Oncological Science, Icahn School of Medicine at Mount Sinai; New York, NY, 10016, USA.
  3. Research Center for Translational Medicine; Shanghai East Hospital of Tongji University School of Medicine; Shanghai, China.
  4. Department of Environmental Health Sciences, Columbia University; New York, NY, 10027, USA.
  5. Department of Nutrition, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA.
  6. Department of Epidemiology, Columbia University; New York, NY, 10027, USA.
  7. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai; New York, NY, 10016, USA.
  8. Department of Epidemiology, Columbia University; New York, NY, 10027, USA ; Department of Medicine, Columbia University; New York, NY, 10027, USA.
  9. Department of Pathology, Columbia University; New York, NY, 10027, USA.

PMID: 26005715 PMCID: PMC4440485 DOI: 10.23937/2378-3419/2/1/1013

Abstract

INTRODUCTION: Breast cancer, the leading cancer diagnosis among American women, is positively associated with postmenopausal obesity and little or no recreational physical activity (RPA). However, the underlying mechanisms of these associations remain unresolved. Aberrant changes in DNA methylation may represent an early event in carcinogenesis, but few studies have investigated associations between obesity/RPA and gene methylation, particularly in postmenopausal breast tumors where these lifestyle factors are most relevant.

METHODS: We used case-case unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CI) for the associations between body mass index (BMI=weight [kg]/height [m

RESULTS: BMI 25-29.9kg/m

DISCUSSION: While biologically plausible, our findings that BMI is associated with methylated

Keywords: Body mass index; breast cancer; epidemiology; gene methylation; physical activity

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