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Go H, Ryuk JA, Lee HW, et al. Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells. Evid Based Complement Alternat Med. 2015;2015:321407doi: 10.1155/2015/321407.
Go, H., Ryuk, J. A., Lee, H. W., Park, I. S., Kil, K. J., Park, S., Kim, D. I., & Ko, B. S. (2015). Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells. Evidence-based complementary and alternative medicine : eCAM, 2015321407. https://doi.org/10.1155/2015/321407
Go, Hiroe, et al. "Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 321407. doi: https://doi.org/10.1155/2015/321407
Go H, Ryuk JA, Lee HW, Park IS, Kil KJ, Park S, Kim DI, Ko BS. Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells. Evid Based Complement Alternat Med. 2015;2015:321407. doi: 10.1155/2015/321407. Epub 2015 Apr 22. PMID: 25977697; PMCID: PMC4421029.
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Evid Based Complement Alternat Med. 2015;2015:321407. doi: 10.1155/2015/321407. Epub 2015 Apr 22.

Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells.

Evidence-based complementary and alternative medicine : eCAM

Hiroe Go, Jin Ah Ryuk, Hye Won Lee, In Sil Park, Ki-Jung Kil, Sunmin Park, Dong Il Kim, Byoung Seob Ko

Affiliations

  1. Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea.
  2. College of Oriental Medicine, Joongbu University, 201 Daehak-Ro, Chubu-Myeon, Geumsan-Gun, ChungNam 312-702, Republic of Korea.
  3. Food and Nutrition, Obesity/Diabetes Center, Hoseo University, 165 Sechul-Ri, Bae Bang-Yup, Asan-Si, Chungcheongnam-do 336-795, Republic of Korea.
  4. Dongguk University Ilsan Oriental Hospital, 27 Dongguk-Ro, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do 410-773, Republic of Korea.

PMID: 25977697 PMCID: PMC4421029 DOI: 10.1155/2015/321407

Abstract

The present study was conducted to investigate the effect of Sagunja-tang on the lipid related disease in a rat model of menopausal hyperlipidemia and lipid accumulation in methyl-β-cyclodextrin-induced HepG2 cells. In in vivo study using menopausal hyperlipidemia rats, Sagunja-tang reduced retroperitoneal and perirenal fat, serum lipids, atherogenic index, cardiac risk factor, media thickness, and nonalcoholic steatohepatitis score, when compared to menopausal hyperlipidemia control rats. In HepG2 cells, Sagunja-tang significantly decreased the lipid accumulation, total cholesterol levels, and low-density/very-low-density lipoprotein levels. Moreover, Sagunja-tang reversed the methyl-β-cyclodextrin-induced decrease in the protein levels of critical molecule involved in cholesterol synthesis, sterol regulatory element binding protein-2, and low-density lipoprotein receptor and inhibited protein levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase as well as activity. Phosphorylation level of AMP-activated protein kinase was stimulated by Sagunja-tang. These results suggest that Sagunja-tang has effect on inhibiting hepatic lipid accumulation through regulation of cholesterol synthesis and AMPK activity in vitro. These observations support the idea that Sagunja-tang is bioavailable both in vivo and in vitro and could be developed as a preventive and therapeutic agent of hyperlipidemia in postmenopausal females.

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