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Tong S, Zhang H, Shen M, et al. Application and comparison of high-speed countercurrent chromatography and high performance liquid chromatography in preparative enantioseparation of α-substitution mandelic acids. Sep Sci Technol. 2015;50(5):735-743doi: 10.1080/01496395.2014.959602.
Tong, S., Zhang, H., Shen, M., Ito, Y., & Yan, J. (2015). Application and comparison of high-speed countercurrent chromatography and high performance liquid chromatography in preparative enantioseparation of α-substitution mandelic acids. Separation science and technology, 50(5), 735-743. https://doi.org/10.1080/01496395.2014.959602
Tong, Shengqiang, et al. "Application and comparison of high-speed countercurrent chromatography and high performance liquid chromatography in preparative enantioseparation of α-substitution mandelic acids." Separation science and technology vol. 50,5 (2015): 735-743. doi: https://doi.org/10.1080/01496395.2014.959602
Tong S, Zhang H, Shen M, Ito Y, Yan J. Application and comparison of high-speed countercurrent chromatography and high performance liquid chromatography in preparative enantioseparation of α-substitution mandelic acids. Sep Sci Technol. 2015 Apr 01;50(5):735-743. doi: 10.1080/01496395.2014.959602. PMID: 25983356; PMCID: PMC4428595.
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Sep Sci Technol. 2015 Apr 01;50(5):735-743. doi: 10.1080/01496395.2014.959602.

Application and comparison of high-speed countercurrent chromatography and high performance liquid chromatography in preparative enantioseparation of α-substitution mandelic acids.

Separation science and technology

Shengqiang Tong, Hu Zhang, Mangmang Shen, Yoichiro Ito, Jizhong Yan

Affiliations

  1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310032, China ; Laboratory of Bioseparation Tecnology, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  2. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310032, China.
  3. Laboratory of Bioseparation Tecnology, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 25983356 PMCID: PMC4428595 DOI: 10.1080/01496395.2014.959602

Abstract

Preparative enantioseparations of α-cyclopentylmandelic acid and α-methylmandelic acid by high-speed countercurrent chromatography (HSCCC) and high performance liquid chromatography (HPLC) were compared using hydroxypropy-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD) as the chiral mobile phase additives. In preparative HPLC the enantioseparation was achieved on the ODS C

Keywords: High performance liquid chromatography; High-speed countercurrent chromatography; Preparative enantioseparation; α-Cyclopentylmandelic acid; α-Methylmandelic acid

References

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