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Bakalova R, Lazarova D, Nikolova B, et al. Delivery of size-controlled long-circulating polymersomes in solid tumours, visualized by quantum dots and optical imaging . Biotechnol Biotechnol Equip. 2014;29(1):175-180doi: 10.1080/13102818.2014.984894.
Bakalova, R., Lazarova, D., Nikolova, B., Atanasova, S., Zlateva, G., Zhelev, Z., & Aoki, I. (2015). Delivery of size-controlled long-circulating polymersomes in solid tumours, visualized by quantum dots and optical imaging . Biotechnology, biotechnological equipment, 29(1), 175-180. https://doi.org/10.1080/13102818.2014.984894
Bakalova, Rumiana, et al. "Delivery of size-controlled long-circulating polymersomes in solid tumours, visualized by quantum dots and optical imaging ." Biotechnology, biotechnological equipment vol. 29,1 (2015): 175-180. doi: https://doi.org/10.1080/13102818.2014.984894
Bakalova R, Lazarova D, Nikolova B, Atanasova S, Zlateva G, Zhelev Z, Aoki I. Delivery of size-controlled long-circulating polymersomes in solid tumours, visualized by quantum dots and optical imaging . Biotechnol Biotechnol Equip. 2015 Jan 02;29(1):175-180. doi: 10.1080/13102818.2014.984894. Epub 2014 Nov 26. PMID: 26019630; PMCID: PMC4434099.
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Biotechnol Biotechnol Equip. 2015 Jan 02;29(1):175-180. doi: 10.1080/13102818.2014.984894. Epub 2014 Nov 26.

Delivery of size-controlled long-circulating polymersomes in solid tumours, visualized by quantum dots and optical imaging .

Biotechnology, biotechnological equipment

Rumiana Bakalova, Desislava Lazarova, Biliana Nikolova, Severina Atanasova, Genoveva Zlateva, Zhivko Zhelev, Ichio Aoki

Affiliations

  1. Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa , Chiba , Japan ; Department of Physics, Biophysics and Roentgenology, Faculty of Medicine, Sofia University "St Kliment Ohridski" , Sofia , Bulgaria.
  2. Department of Physics, Biophysics and Roentgenology, Faculty of Medicine, Sofia University "St Kliment Ohridski" , Sofia , Bulgaria.
  3. Department of Electroinduced and Adhesive Properties, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences , Sofia , Bulgaria.
  4. Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa , Chiba , Japan ; Department of Electroinduced and Adhesive Properties, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences , Sofia , Bulgaria ; Department of Medicinal Chemistry and Biochemistry, Faculty of Medicine, Trakia University , Stara Zagora , Bulgaria.
  5. Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa , Chiba , Japan.

PMID: 26019630 PMCID: PMC4434099 DOI: 10.1080/13102818.2014.984894

Abstract

The present study was designed to investigate whether poly-ion complex hollow vesicles (polymersomes), based on chemically modified chitosan, are appropriate for passive tumour targeting in the context of their application as drug carriers. The experiments were performed on colon cancer-grafted mice. The mice were subjected to anaesthesia and injected intravenously with water-soluble nanoparticles: (1) QD

Keywords: cancer; drug-delivery systems; fluorescent imaging; nanoparticles; polymersomes; quantum dot

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