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Adachi Y, Mizutani Y, Shu E, et al. Eosinophilic fasciitis associated with myositis. Case Rep Dermatol. 2015;7(1):79-83doi: 10.1159/000381845.
Adachi, Y., Mizutani, Y., Shu, E., Kanoh, H., Miyazaki, T., & Seishima, M. (2015). Eosinophilic fasciitis associated with myositis. Case reports in dermatology, 7(1), 79-83. https://doi.org/10.1159/000381845
Adachi, Yuko, et al. "Eosinophilic fasciitis associated with myositis." Case reports in dermatology vol. 7,1 (2015): 79-83. doi: https://doi.org/10.1159/000381845
Adachi Y, Mizutani Y, Shu E, Kanoh H, Miyazaki T, Seishima M. Eosinophilic fasciitis associated with myositis. Case Rep Dermatol. 2015 Apr 30;7(1):79-83. doi: 10.1159/000381845. eCollection 2015. PMID: 26034478; PMCID: PMC4448070.
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Case Rep Dermatol. 2015 Apr 30;7(1):79-83. doi: 10.1159/000381845. eCollection 2015.

Eosinophilic fasciitis associated with myositis.

Case reports in dermatology

Yuko Adachi, Yoko Mizutani, En Shu, Hiroyuki Kanoh, Tatsuhiko Miyazaki, Mariko Seishima

Affiliations

  1. Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
  2. Division of Pathology, Gifu University Hospital, Gifu, Japan.

PMID: 26034478 PMCID: PMC4448070 DOI: 10.1159/000381845

Abstract

Eosinophilic fasciitis is clinically characterized by symmetrical scleroderma-like indurations of the skin with pain. The histological features are fascial inflammation with lymphocytes and eosinophils as well as thickened and fibrotic fascia. Lymphocytic infiltration and degeneration of the underlying muscle are rarely observed. We report a 69-year-old Japanese woman who presented with multiple areas of glossy induration and painful peau d'orange-like lesions on the chest and four extremities. T2-weighted magnetic resonance imaging showed significant hyperintense thickening of the fascia of the lower extremities. Histopathological examination of a biopsy specimen from the induration showed marked fibrinoid degeneration of the fascia and the neighboring muscle with mixed cellular infiltration of lymphocytes and eosinophils. The predominant CD8+ lymphocytic infiltrates were observed by immunohistological study. A diagnosis of eosinophilic fasciitis with myositis was made. Oral administration of prednisolone and discontinuation of exercise significantly improved the lesions and pain.

Keywords: Eosinophilic fasciitis; Exercise; Magnetic resonance imaging; Myositis

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