Display options
Cite
Ayina Ayina CN, Sobngwi E, Essouma M, et al. Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity. Diabetol Metab Syndr. 2015;7:47doi: 10.1186/s13098-015-0042-3.
Ayina Ayina, C. N., Sobngwi, E., Essouma, M., Noubiap, J. J., Boudou, P., Etoundi Ngoa, L. S., & Gautier, J. F. (2015). Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity. Diabetology & metabolic syndrome, 747. https://doi.org/10.1186/s13098-015-0042-3
Ayina Ayina, Clarisse Noël, et al. "Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity." Diabetology & metabolic syndrome vol. 7 (2015): 47. doi: https://doi.org/10.1186/s13098-015-0042-3
Ayina Ayina CN, Sobngwi E, Essouma M, Noubiap JJ, Boudou P, Etoundi Ngoa LS, Gautier JF. Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity. Diabetol Metab Syndr. 2015 May 23;7:47. doi: 10.1186/s13098-015-0042-3. eCollection 2015. PMID: 26034511; PMCID: PMC4450452.
Copy Download .nbib Format: NLM
Share it on

Diabetol Metab Syndr. 2015 May 23;7:47. doi: 10.1186/s13098-015-0042-3. eCollection 2015.

Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity.

Diabetology & metabolic syndrome

Clarisse Noël Ayina Ayina, Eugene Sobngwi, Mickael Essouma, Jean Jacques N Noubiap, Philippe Boudou, Laurent Serge Etoundi Ngoa, Jean François Gautier

Affiliations

  1. Department of Animal Science, Faculty of Science, University of Douala, Douala, Cameroon.
  2. Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon ; Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon ; National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon.
  3. Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
  4. Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa ; Medical Diagnostic Center, Yaoundé, Cameroon.
  5. Department of Hormonal Biology, Saint-Louis Hospital, Public Assistance - Paris Hospitals, University Paris-Diderot Paris-7, Paris, France ; Department of Diabetes and Endocrinology, Saint-Louis Hospital, Public Assistance - Paris Hospitals, University Paris-Diderot Paris-7, Paris, France.
  6. Department of Animal Science, Higher Teacher's Training College, University of Yaoundé I, Yaoundé, Cameroon.
  7. Department of Diabetes and Endocrinology, Saint-Louis Hospital, Public Assistance - Paris Hospitals, University Paris-Diderot Paris-7, Paris, France ; INSERM UMRS 1138, Cordeliers Research Centre, University Pierre et Marie Curie-Paris 6, Paris, France.

PMID: 26034511 PMCID: PMC4450452 DOI: 10.1186/s13098-015-0042-3

Abstract

BACKGROUND: Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily that inhibits bone resorption, has been suggested as a potential marker of cardiovascular risk. This study aimed to assess the relationship between insulin resistance, lipid profile and OPG levels in obese and non-obese sub-Saharan African women.

METHODS: Sixty obese (44) and non-obese (16) volunteer women aged 18 to 40 years were recruited in this cross-sectional study. Their clinical (age, height, weight, waist circumference, systolic and diastolic blood pressures) and biochemical parameters (fasting blood glucose, total cholesterol, high density lipoprotein-cholesterol (HDL-C)) were measured using standard methods. Insulin levels were measured using an electrochemiluminescence immunoassay, while OPG levels were measured using the ELISA technique. Low density lipoprotein-cholesterol (LDL-C), body mass index (BMI) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) were calculated using standard methods. Abdominal obesity was defined as a waist circumference ≥ 80 cm.

RESULTS: OPG levels were higher in obese than in normal subjects, though the difference was not significant (p = 0.9). BMI, waist circumference, percent body fat and systolic blood pressure were significantly higher in obese than in non-obese subjects (p < 0.05). In these subjects, only age significantly correlated with OPG levels (r = 0.831, p = 0.003), while none of the anthropometric nor metabolic parameter did, even after adjustment for age. In obese subjects, OPG levels fairly correlated with HDL-C (r = 0.298, p = 0.058), and significantly correlated with HOMA-IR (r = -0.438, p = 0.018). After adjustment for age, OPG levels remained negatively correlated to HOMA-IR (r = -0.516, p = 0.020) and LDL-C (r = -0.535, p = 0.015) and positively correlated to HDL-C (r = 0.615, p = 0.004). In multiple linear regression analysis, age was a main determinant of OPG levels in non-obese (β = 0.647, p = 0.006) and obese (β = 0.356, p = 0.044) women. HDL-C was also associated to OPG levels in obese women (β = 0.535, p = 0.009).

CONCLUSION: The positive correlation of OPG with HDL-C and HOMA-IR, and its negative correlation with LDL-C suggest that it may be a marker of insulin sensitivity/resistance and atherogenic risk in obese African women.

Keywords: Insulin resistance; Lipids; Obesity; Osteoprotegerin; Sub-Saharan Africans

References

  1. Clin Chem. 1972 Jun;18(6):499-502 - PubMed
  2. Clin Exp Rheumatol. 2015 Mar-Apr;33(2):241-9 - PubMed
  3. Eur J Endocrinol. 2011 Jan;164(1):69-74 - PubMed
  4. Springerplus. 2013 Dec 06;2:658 - PubMed
  5. Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2117-24 - PubMed
  6. J Rheumatol. 2015 Jan;42(1):39-45 - PubMed
  7. J Clin Endocrinol Metab. 2000 Jul;85(7):2355-63 - PubMed
  8. FASEB J. 1998 Jul;12(10):845-54 - PubMed
  9. Cell. 1998 Apr 17;93(2):165-76 - PubMed
  10. Can J Cardiol. 2014 Dec;30(12 ):1529-34 - PubMed
  11. Biomarkers. 2015 Mar;20(2):116-22 - PubMed
  12. Atherosclerosis. 2009 Jun;204(2):321-9 - PubMed
  13. Expert Rev Cardiovasc Ther. 2006 Nov;4(6):801-11 - PubMed
  14. Clin Endocrinol (Oxf). 2006 Jun;64(6):652-8 - PubMed
  15. Diabetes Metab. 2011 Jun;37(3):179-88 - PubMed
  16. Circulation. 2008 Jan 22;117(3):411-20 - PubMed
  17. Circ Heart Fail. 2011 Mar;4(2):145-52 - PubMed
  18. Ann Endocrinol (Paris). 2014 Jul;75(3):165-70 - PubMed
  19. Eur J Endocrinol. 2008 Mar;158(3):353-9 - PubMed
  20. Trans Am Clin Climatol Assoc. 2011;122:256-89 - PubMed
  21. BMC Endocr Disord. 2014 Aug 09;14:65 - PubMed

Publication Types