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Kim KT, Jang HJ, Lee JE, et al. Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy. Intest Res. 2015;13(3):287-90doi: 10.5217/ir.2015.13.3.287.
Kim, K. T., Jang, H. J., Lee, J. E., Kim, M. K., Yoo, J. J., Lee, G. Y., Kae, S. H., & Lee, J. (2015). Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy. Intestinal research, 13(3), 287-90. https://doi.org/10.5217/ir.2015.13.3.287
Kim, Kwang Taek, et al. "Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy." Intestinal research vol. 13,3 (2015): 287-90. doi: https://doi.org/10.5217/ir.2015.13.3.287
Kim KT, Jang HJ, Lee JE, Kim MK, Yoo JJ, Lee GY, Kae SH, Lee J. Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy. Intest Res. 2015 Jul;13(3):287-90. doi: 10.5217/ir.2015.13.3.287. Epub 2015 Jun 09. PMID: 26131005; PMCID: PMC4479745.
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Intest Res. 2015 Jul;13(3):287-90. doi: 10.5217/ir.2015.13.3.287. Epub 2015 Jun 09.

Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy.

Intestinal research

Kwang Taek Kim, Hyun Joo Jang, Jae Eun Lee, Mi Kang Kim, Jun Jae Yoo, Gye Yeon Lee, Sea Hyub Kae, Jin Lee

Affiliations

  1. Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

PMID: 26131005 PMCID: PMC4479745 DOI: 10.5217/ir.2015.13.3.287

Abstract

Familial Mediterranean fever (FMF) is an inherited autosomal recessive disorder, ethnically restricted and commonly found among populations surrounding the Mediterranean Sea. FMF is the most prevalent autoinflammatory disease; is characterized by recurrent, self-limited episodes of fever with serositis; and is caused by Mediterranean fever gene (MEFV) mutations on chromosome 16. We describe a case of adult-onset FMF with complete symptomatic remission during pregnancy, without the use of colchicine. A 25-year-old woman had presented with periodic fever, abdominal pain, and vomiting since she was 21. Her abdominal computed tomography scan showed intestinal nonrotation. She underwent exploratory laparotomy and appendectomy for her symptoms 1 year prior. She had a symptom-free pregnancy period, but abdominal pain and fever recurred after delivery. Mutation analysis of the MEFV gene revealed two point mutations (p.Leu110Pro and p.Glu148Gln). We report an adult female patient with FMF in Korea with complete symptomatic remission during pregnancy.

Keywords: Familial Mediterranean fever; MEFV gene; Periodic fever syndrome; Pregnancy

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