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Fan J, Zhang W, Lei C, et al. Vascular endothelial growth factor polymorphisms and lung cancer risk. Int J Clin Exp Med. 2015;8(4):6406-11
Fan, J., Zhang, W., Lei, C., Qiao, B., Liu, Q., Chen, Q., Jiao, H., Jiang, L., Cui, S., & Chen, J. (2015). Vascular endothelial growth factor polymorphisms and lung cancer risk. International journal of clinical and experimental medicine, 8(4), 6406-11.
Fan, Junli, et al. "Vascular endothelial growth factor polymorphisms and lung cancer risk." International journal of clinical and experimental medicine vol. 8,4 (2015): 6406-11.
Fan J, Zhang W, Lei C, Qiao B, Liu Q, Chen Q, Jiao H, Jiang L, Cui S, Chen J. Vascular endothelial growth factor polymorphisms and lung cancer risk. Int J Clin Exp Med. 2015 Apr 15;8(4):6406-11. eCollection 2015. PMID: 26131266; PMCID: PMC4483952.
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Int J Clin Exp Med. 2015 Apr 15;8(4):6406-11. eCollection 2015.

Vascular endothelial growth factor polymorphisms and lung cancer risk.

International journal of clinical and experimental medicine

Junli Fan, Weiguo Zhang, Caipeng Lei, Bin Qiao, Qin Liu, Qiang Chen, Hongduo Jiao, Leizhen Jiang, Shuo Cui, Jianmin Chen

Affiliations

  1. Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
  2. Department of Neurosurgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
  3. Microsurgical Ward Section, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.

PMID: 26131266 PMCID: PMC4483952

Abstract

The VEGF polymorphisms has been implicated in the susceptibility to lung cancer, but the results are not conclusive. The aim of this study is to investigate the association between the VEGF polymorphisms and the risk of lung cancer by meta-analysis. We searched PubMed, Embase, CNKI and Wanfang databases. A total of 7 case-control studies were included in this meta-analysis. We found that VEGF rs833061 polymorphism showed no significant association with lung cancer risk. Subgroup analysis on race suggested that CC genotype was significantly associated with lung cancer risk in Asian population. We found that VEGF rs699947 polymorphism showed significant association with lung cancer risk. Subgroup analysis on race showed that VEGF rs699947 polymorphism increased lung cancer risk in Asians. In conclusion, this meta-analysis suggested that the VEGF rs699947 is associated with increased risk of lung cancer.

Keywords: Lung cancer; VEGF; meta-analysis

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