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Erramuzpe A, Encinas JM, Sierra A, et al. Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy. F1000Res. 2015;4:144doi: 10.12688/f1000research.6570.1.
Erramuzpe, A., Encinas, J. M., Sierra, A., Maletic-Savatic, M., Brewster, A. L., Anderson, A. E., Stramaglia, S., & Cortes, J. M. (2015). Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy. F1000Research, 4144. https://doi.org/10.12688/f1000research.6570.1
Erramuzpe, A, et al. "Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy." F1000Research vol. 4 (2015): 144. doi: https://doi.org/10.12688/f1000research.6570.1
Erramuzpe A, Encinas JM, Sierra A, Maletic-Savatic M, Brewster AL, Anderson AE, Stramaglia S, Cortes JM. Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy. F1000Res. 2015 Jun 05;4:144. doi: 10.12688/f1000research.6570.1. eCollection 2015. PMID: 26167275; PMCID: PMC4482210.
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F1000Res. 2015 Jun 05;4:144. doi: 10.12688/f1000research.6570.1. eCollection 2015.

Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy.

F1000Research

A Erramuzpe, J M Encinas, A Sierra, M Maletic-Savatic, A L Brewster, Anne E Anderson, S Stramaglia, Jesus M Cortes

Affiliations

  1. Biocruces Health Research Institute, Cruces University Hospital, Barakaldo, 48903, Spain.
  2. Achucarro Basque Center for Neuroscience, Zamudio, 48170, Spain ; University of the Basque Country (UPV/EHU), Leioa, 48940, Spain ; Ikerbasque: The Basque Foundation for Science, Bilbao, 48013, Spain.
  3. Neurological Research Institute, Baylor College of Medicine, Houston, Texas, 77030, USA.
  4. Dipartimento di Fisica, Universita degla Studi di Bari and INFN, Bari, 70125, Italy ; BCAM, Basque Center for Applied Mathematics, Bilbao, 48009, Spain.
  5. Biocruces Health Research Institute, Cruces University Hospital, Barakaldo, 48903, Spain ; University of the Basque Country (UPV/EHU), Leioa, 48940, Spain ; Ikerbasque: The Basque Foundation for Science, Bilbao, 48013, Spain.

PMID: 26167275 PMCID: PMC4482210 DOI: 10.12688/f1000research.6570.1

Abstract

Brain Functional Connectivity (FC) quantifies statistical dependencies between areas of the brain. FC has been widely used to address altered function of brain circuits in control conditions compared to different pathological states, including epilepsy, a major neurological disorder. However, FC also has the as yet unexplored potential to help us understand the pathological transformation of the brain circuitry. Our hypothesis is that FC can differentiate global brain interactions across a time-scale of days. To this end, we present a case report study based on a mouse model for epilepsy and analyze longitudinal intracranial electroencephalography data of epilepsy to calculate FC across three stages:   1, the initial insult (status epilepticus); 2, the latent period, when epileptogenic networks emerge; and 3, chronic epilepsy, when unprovoked seizures occur as spontaneous events. We found that the overall network FC at low frequency bands decreased immediately after status epilepticus was provoked, and increased monotonously later on during the latent period. Overall, our results demonstrate the capacity  of FC to address longitudinal variations of brain connectivity across the establishment of pathological states.

Keywords: Longitudinal study; brain functional connectivity; mouse brain connectivity; mouse model; temporal lobe epilepsy

References

  1. Phys Rev Lett. 2010 Mar 19;104(11):118701 - PubMed
  2. Cereb Cortex. 2004 Aug;14(8):892-902 - PubMed
  3. Front Hum Neurosci. 2013 Oct 01;7:624 - PubMed
  4. IEEE Trans Biomed Eng. 2011 Nov;58(11):3088-96 - PubMed
  5. PLoS One. 2012;7(7):e41799 - PubMed
  6. Ann Neurol. 2006 Feb;59(2):335-43 - PubMed
  7. Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94 - PubMed
  8. Cell Stem Cell. 2015 May 7;16(5):488-503 - PubMed
  9. Hum Brain Mapp. 2009 May;30(5):1580-91 - PubMed
  10. Front Neuroinform. 2013 Nov 13;7:24 - PubMed
  11. Eur J Pharmacol. 1978 Aug 1;50(3):209-20 - PubMed
  12. Neuroscience. 1985 Feb;14(2):375-403 - PubMed
  13. Neuroscience. 1999 Mar;89(3):717-29 - PubMed

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