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Showing 1 to 12 of 845 entries
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Comparison of enzymatic properties and small molecule inhibition of γ-glutamyltranspeptidases from pathogenic and commensal bacteria.

Biological chemistry

Bolz C, Bach NC, Meyer H, Müller G, Dawidowski M, Popowicz G, Sieber SA, Skerra A, Gerhard M.
PMID: 27636829
Biol Chem. 2017 Mar;398(3):341-357. doi: 10.1515/hsz-2016-0198.

Helicobacter pylori infects the stomach of 50% of the population worldwide, thus causing chronic gastritis. Although this infection can be cured by antibiotic treatment, therapeutic options are increasingly limited due to the development of resistances. The γ-glutamyl-transpeptidase (gGT) of...

Cost-effectiveness analysis of azacitidine in the treatment of high-risk myelodysplastic syndromes in Spain.

Health economics review

Crespo C, Moreno E, Sierra J, Serip S, Rubio M.
PMID: 24314138
Health Econ Rev. 2013 Dec 05;3(1):28. doi: 10.1186/2191-1991-3-28.

BACKGROUND: The objective of the study was to analyse whether azacitidine is a cost-effective option for the treatment of myelodysplastic syndrome in the Spanish setting compared with conventional care regimens, including best supportive care, low dose chemotherapy and standard...

Correction: Long-Term Safety of Repeated Blood-Brain Barrier Opening via Focused Ultrasound with Microbubbles in Non-Human Primates Performing a Cognitive Task.

PloS one

Downs ME, Buch A, Sierra C, Karakatsani ME, Teichert T, Chen S, Konofagou EE, Ferrera VP.
PMID: 26087322
PLoS One. 2015 Jun 18;10(6):e0130860. doi: 10.1371/journal.pone.0130860. eCollection 2015.

No abstract available.

Corrigendum: Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients.

The American journal of gastroenterology

Comino I, Fernández-Bañares F, Esteve M, Ortigosa L, Castillejo G, Fambuena B, Ribes-Koninckx C, Sierra C, Rodríguez-Herrera A, Salazar JC, Caunedo Á, Marugán-Miguelsanz JM, Garrote JA, Vivas S, Lo Iacono O, Nuñez A, Vaquero L, Vegas AM, Crespo L, Fernández-Salazar L, Arranz E, Jiménez-García VA, Montes-Cano MA, Espín B, Galera A, Valverde J, José Girón F, Bolonio M, Millán A, Cerezo FM, Guajardo C, Alberto JR, Rosinach M, Segura V, León F, Marinich J, Muñoz-Suano A, Romero-Gómez M, Cebolla Á, Sousa C.
PMID: 28397876
Am J Gastroenterol. 2017 Jul;112(7):1208. doi: 10.1038/ajg.2017.110. Epub 2017 Apr 11.

This corrects the article DOI: 10.1038/ajg.2016.439.

Sequential Reactions of Alkynes on an Iridium(III) Single Site.

Chemistry (Weinheim an der Bergstrasse, Germany)

Giner EA, Gómez-Gallego M, Merinero AD, Casarrubios L, Ramírez de Arellano C, Sierra MA.
PMID: 28440592
Chemistry. 2017 Jul 03;23(37):8941-8948. doi: 10.1002/chem.201701100. Epub 2017 Jun 12.

Sequential insertion of terminal alkynes on Ir

Case Study: Remission of Type 2 Diabetes After Outpatient Basal Insulin Therapy.

Diabetes spectrum : a publication of the American Diabetes Association

Schmidt SC, Ann Huey M, Whitley HP.
PMID: 26912966
Diabetes Spectr. 2016 Feb;29(1):50-3. doi: 10.2337/diaspect.29.1.50.

No abstract available.

Emotional Experience and Awareness of Self: Functional MRI Studies of Depersonalization Disorder.

Frontiers in psychology

Medford N, Sierra M, Stringaris A, Giampietro V, Brammer MJ, David AS.
PMID: 27313548
Front Psychol. 2016 Jun 02;7:432. doi: 10.3389/fpsyg.2016.00432. eCollection 2016.

This paper presents functional MRI work on emotional processing in depersonalization disorder (DPD). This relatively neglected disorder is hallmarked by a disturbing change in the quality of first-person experience, almost invariably encompassing a diminished sense of self and an...

An Entry to Mixed NHC-Fischer Carbene Complexes and Zwitterionic Group 6 Metal Alkenyls.

Chemistry (Weinheim an der Bergstrasse, Germany)

Sierra MA, Merinero AD, Giner EA, Gómez-Gallego M, Ramírez de Arellano C.
PMID: 27459647
Chemistry. 2016 Sep 12;22(38):13521-31. doi: 10.1002/chem.201601735. Epub 2016 Jul 26.

The addition of NHCs to α,β-unsaturated Cr(0) and W(0) (Fischer) carbene complexes is strongly dependent on the electrophilicity of the carbene carbon. Electrophilic alkoxy-carbene complexes quantitatively react with NHCs to yield stable zwitterionic (racemic) Cr(0) - and W(0) -alkenyls...

Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat.

Frontiers in neuroscience

Laitinen T, Sierra A, Bolkvadze T, Pitkänen A, Gröhn O.
PMID: 25954146
Front Neurosci. 2015 Apr 22;9:128. doi: 10.3389/fnins.2015.00128. eCollection 2015.

Traumatic brain injury (TBI) is a major cause of disability and death in people of all ages worldwide. An initial brain injury caused by external mechanical forces triggers a cascade of tissue changes that lead to a wide spectrum...

Enriched biodiversity data as a resource and service.

Biodiversity data journal

Vos RA, Biserkov JV, Balech B, Beard N, Blissett M, Brenninkmeijer C, van Dooren T, Eades D, Gosline G, Groom QJ, Hamann TD, Hettling H, Hoehndorf R, Holleman A, Hovenkamp P, Kelbert P, King D, Kirkup D, Lammers Y, DeMeulemeester T, Mietchen D, Miller JA, Mounce R, Nicolson N, Page R, Pawlik A, Pereira S, Penev L, Richards K, Sautter G, Shorthouse DP, Tähtinen M, Weiland C, Williams AR, Sierra S.
PMID: 25057255
Biodivers Data J. 2014 Jun 16;(2):e1125. doi: 10.3897/BDJ.2.e1125. eCollection 2014.

BACKGROUND: Recent years have seen a surge in projects that produce large volumes of structured, machine-readable biodiversity data. To make these data amenable to processing by generic, open source "data enrichment" workflows, they are increasingly being represented in a...

Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy.

F1000Research

Erramuzpe A, Encinas JM, Sierra A, Maletic-Savatic M, Brewster AL, Anderson AE, Stramaglia S, Cortes JM.
PMID: 26167275
F1000Res. 2015 Jun 05;4:144. doi: 10.12688/f1000research.6570.1. eCollection 2015.

Brain Functional Connectivity (FC) quantifies statistical dependencies between areas of the brain. FC has been widely used to address altered function of brain circuits in control conditions compared to different pathological states, including epilepsy, a major neurological disorder. However,...

Stereoselective Synthesis of 3-Substituted 4-(Formyloxy)-2-azetidinones by the Unusual Baeyer-Villiger Reaction of beta-Lactam Aldehydes. Scope and Synthetic Applications.

The Journal of organic chemistry

Alcaide B, Aly MF, Sierra MA.
PMID: 11667860
J Org Chem. 1996 Dec 13;61(25):8819-8825. doi: 10.1021/jo9612685.

The Baeyer-Villiger oxidation of 4-formyl-beta-lactams 1with m-CPBA gave 4-(formyloxy) beta-lactams 2 in a simple, efficient, and totally stereoselective process. This reaction is one of the scarce examples of the preferred migration of a carbon moiety in an aliphatic aldehyde....

Showing 1 to 12 of 845 entries