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Wu AA, Drake V, Huang HS, et al. Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells. Oncoimmunology. 2015;4(7):e1016700doi: 10.1080/2162402X.2015.1016700.
Wu, A. A., Drake, V., Huang, H. S., Chiu, S., & Zheng, L. (2015). Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells. Oncoimmunology, 4(7), e1016700. https://doi.org/10.1080/2162402X.2015.1016700
Wu, Annie A, et al. "Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells." Oncoimmunology vol. 4,7 (2015): e1016700. doi: https://doi.org/10.1080/2162402X.2015.1016700
Wu AA, Drake V, Huang HS, Chiu S, Zheng L. Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells. Oncoimmunology. 2015 Apr 01;4(7):e1016700. doi: 10.1080/2162402X.2015.1016700. eCollection 2015 Jul. PMID: 26140242; PMCID: PMC4485788.
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Oncoimmunology. 2015 Apr 01;4(7):e1016700. doi: 10.1080/2162402X.2015.1016700. eCollection 2015 Jul.

Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells.

Oncoimmunology

Annie A Wu, Virginia Drake, Huai-Shiuan Huang, ShihChi Chiu, Lei Zheng

Affiliations

  1. Department of Oncology; The Johns Hopkins University School of Medicine ; Baltimore, MD USA.
  2. School of Medicine; University of Maryland ; Baltimore, MD USA.
  3. College of Medicine; National Taiwan University ; Taipei, Taiwan.

PMID: 26140242 PMCID: PMC4485788 DOI: 10.1080/2162402X.2015.1016700

Abstract

It has become evident that tumor-induced immuno-suppressive factors in the tumor microenvironment play a major role in suppressing normal functions of effector T cells. These factors serve as hurdles that limit the therapeutic potential of cancer immunotherapies. This review focuses on illustrating the molecular mechanisms of immunosuppression in the tumor microenvironment, including evasion of T-cell recognition, interference with T-cell trafficking, metabolism, and functions, induction of resistance to T-cell killing, and apoptosis of T cells. A better understanding of these mechanisms may help in the development of strategies to enhance the effectiveness of cancer immunotherapies.

Keywords: 1MT, 1-methyltryptophan; COX2, cyclooxygenase-2; GM-CSF, granulocyte macrophage colony-stimulating factor; GPI, glycosylphosphatidylinositol; Gal1, galectin-1; HDACi, histone deacetylase inhibitor; HLA, human leukocyte antigen; IDO, indoleamine-2,3- dioxygenase; IL-10, interleukin-10; IMC, immature myeloid cell; MDSC, myeloid-derived suppressor cells; MHC, major histocompatibility; MICA, MHC class I related molecule A; MICB, MHC class I related molecule B; NO, nitric oxide; PARP, poly ADP-ribose polymerase; PD-1, program death receptor-1; PD-L1, programmed death ligand 1; PGE2, prostaglandin E2; RCAS1, receptor-binding cancer antigen expressed on Siso cells 1; RCC, renal cell carcinoma; SOCS, suppressor of cytokine signaling; STAT3, signal transducer and activator of transcription 3; SVV, survivin; T cells; TCR, T-cell receptor; TGF-β, transforming growth factor β; TRAIL, TNF-related apoptosis-inducing ligand; VCAM-1, vascular cell adhesion molecule-1; XIAP, X-linked inhibitor of apoptosis protein; iNOS, inducible nitric-oxide synthase; immunosuppression; immunosuppressive factors; immunotherapy; tumor microenvironment

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