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Kanda T, Nakamoto S, Arai M, et al. Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient. Clin J Gastroenterol. 2013;6(2):160-3doi: 10.1007/s12328-013-0366-1.
Kanda, T., Nakamoto, S., Arai, M., Miyamura, T., Wu, S., Fujiwara, K., & Yokosuka, O. (2013). Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient. Clinical journal of gastroenterology, 6(2), 160-3. https://doi.org/10.1007/s12328-013-0366-1
Kanda, Tatsuo, et al. "Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient." Clinical journal of gastroenterology vol. 6,2 (2013): 160-3. doi: https://doi.org/10.1007/s12328-013-0366-1
Kanda T, Nakamoto S, Arai M, Miyamura T, Wu S, Fujiwara K, Yokosuka O. Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient. Clin J Gastroenterol. 2013 Apr;6(2):160-3. doi: 10.1007/s12328-013-0366-1. Epub 2013 Feb 17. PMID: 26181455.
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Clin J Gastroenterol. 2013 Apr;6(2):160-3. doi: 10.1007/s12328-013-0366-1. Epub 2013 Feb 17.

Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient.

Clinical journal of gastroenterology

Tatsuo Kanda, Shingo Nakamoto, Makoto Arai, Tatsuo Miyamura, Shuang Wu, Keiichi Fujiwara, Osamu Yokosuka

Affiliations

  1. Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan. [email protected].
  2. Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.

PMID: 26181455 DOI: 10.1007/s12328-013-0366-1

Abstract

We describe a patient infected with hepatitis C virus (HCV) genotype 1 who failed to respond to interferon with or without ribavirin seven times but who then achieved sustained virological response by the combination of interferon-beta plus ribavirin treatment for 48 weeks. He did not respond to stronger treatment such as prolonged peginterferon plus ribavirin treatment for 87 weeks. It might be rare to treat a patient with interferon 8 times considering the cost and time, since patients failing interferon treatment several times are regarded to be refractory to interferon. It is possible that the difference in biological effects between interferon-alfa and interferon-beta might have resulted in a different outcome in our patient. Interferon-beta plus ribavirin therapy might be one of the treatment options for certain patients chronically infected with HCV who do not respond to standard care treatment.

Keywords: HCV genotype 1; Hepatitis C; Interferon-beta; Neutralizing antibody; Ribavirin; Sustained virological response

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