Display options
Cite
Chen BG, Wu MY, Liu RH, et al. Mass Spectra and Cross-Contribution of Ion Intensity Between Drug Analytes and Their Isotopically Labelled Analogs - Common Opioids and Their Derivatives. Forensic Sci Rev. 2008;20(2):75-173
Chen, B. G., Wu, M. Y., Liu, R. H., Wang, S. M., Lewis, R. J., Ritter, R. M., & Canfield, D. V. (2008). Mass Spectra and Cross-Contribution of Ion Intensity Between Drug Analytes and Their Isotopically Labelled Analogs - Common Opioids and Their Derivatives. Forensic science review, 20(2), 75-173.
Chen, B G, et al. "Mass Spectra and Cross-Contribution of Ion Intensity Between Drug Analytes and Their Isotopically Labelled Analogs - Common Opioids and Their Derivatives." Forensic science review vol. 20,2 (2008): 75-173.
Chen BG, Wu MY, Liu RH, Wang SM, Lewis RJ, Ritter RM, Canfield DV. Mass Spectra and Cross-Contribution of Ion Intensity Between Drug Analytes and Their Isotopically Labelled Analogs - Common Opioids and Their Derivatives. Forensic Sci Rev. 2008 Jul;20(2):75-173. PMID: 26247421.
Copy Download .nbib Format: NLM
Share it on

Forensic Sci Rev. 2008 Jul;20(2):75-173.

Mass Spectra and Cross-Contribution of Ion Intensity Between Drug Analytes and Their Isotopically Labelled Analogs - Common Opioids and Their Derivatives.

Forensic science review

B G Chen, M Y Wu, R H Liu, S M Wang, R J Lewis, R M Ritter, D V Canfield

Affiliations

  1. Department of Medical Technology, Fooyin University, Ta-Liao Hsiang, Kaohsiung Hsien, Taiwan.
  2. Department of Forensic Sciences, Central Police University, Kwei-Shan Hsiang, Taiyuan Hsien, Taiwan.
  3. Bioaeronautical Sciences Research Laboratory, FAA Civil Aerospace Medical Institute, Oklahoma City, OK, USA.

PMID: 26247421

Abstract

For the quantitation of most drugs and their metabolites, GC-MS is currently the preferred method and isotopically labeled analogs of the analytes are the internal standards (ISs) of choice. Under this analytical setting, chemical derivatization (CD) plays a critical role in the sample preparation process. In addition to meeting the conventional objectives of CD, products derived from the selected CD method must generate ions suitable for designating the analyte and the IS; these ions cannot have significant cross-contribution (CC), i.e., contribution to the intensity of the ions designating the analyte by the IS, and vice versa. With this in mind, the authors have reviewed literature and information provided by manufacturers, searching for suitable CD reagents, CD methods, and isotopically labeled analogs of the analytes related to the following 11 opioids: heroin, 6-acetylmorphine, morphine, hydromorphone, oxymorphone, 6-acetylcodeine, codeine, hydrocodone, dihydrocodeine, oxycodone, and noroxycodone. These analytes and ISs were derivatized with various derivatization groups, followed by GCMS analysis. The resulting MS data are systematically presented in two forms: (a) full-scan mass spectra; and (b) CC data of ion-pairs with potential for designating the analytes and their respective ISs. Many (if not most) of these full-scan mass spectra are not yet available in the literature and should be of reference value to laboratories engaged in the analysis of these drugs/metabolites. Full-scan MS data were further used to select ion-pairs with potential for designating the analytes and ISs in quantitative analysis protocols. The CC data of these ion-pairs were evaluated using data collected in selected ion monitoring mode and systematically tabulated, readily available for analysts searching for this important analytical parameter.

Copyright © 2008 Central Police University.

Keywords: 6-Acetylcodeine; 6-acetylmorphine; GC-MS; chemical derivatization; codeine; cross-contribution; dihydrocodeine; heroin; hydrocodone; hydromorphone; internal standard; morphine; noroxycodone; opiate; opioid; oxycodone; oxymorphone

Publication Types