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Hamada T, Hagihara H, Morita M, et al. Physicochemical Profiling of Surfactant-Induced Membrane Dynamics in a Cell-Sized Liposome. J Phys Chem Lett. 2012;3(3):430-5doi: 10.1021/jz2016044.
Hamada, T., Hagihara, H., Morita, M., Vestergaard, M. C., Tsujino, Y., & Takagi, M. (2012). Physicochemical Profiling of Surfactant-Induced Membrane Dynamics in a Cell-Sized Liposome. The journal of physical chemistry letters, 3(3), 430-5. https://doi.org/10.1021/jz2016044
Hamada, Tsutomu, et al. "Physicochemical Profiling of Surfactant-Induced Membrane Dynamics in a Cell-Sized Liposome." The journal of physical chemistry letters vol. 3,3 (2012): 430-5. doi: https://doi.org/10.1021/jz2016044
Hamada T, Hagihara H, Morita M, Vestergaard MC, Tsujino Y, Takagi M. Physicochemical Profiling of Surfactant-Induced Membrane Dynamics in a Cell-Sized Liposome. J Phys Chem Lett. 2012 Feb 02;3(3):430-5. doi: 10.1021/jz2016044. Epub 2012 Jan 20. PMID: 26285862.
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J Phys Chem Lett. 2012 Feb 02;3(3):430-5. doi: 10.1021/jz2016044. Epub 2012 Jan 20.

Physicochemical Profiling of Surfactant-Induced Membrane Dynamics in a Cell-Sized Liposome.

The journal of physical chemistry letters

Tsutomu Hamada, Hideyuki Hagihara, Masamune Morita, Mun'delanji C Vestergaard, Yoshio Tsujino, Masahiro Takagi

Affiliations

  1. †School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan.
  2. ‡Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15-8 Shiomi-cho, Choshi, Chiba 288-0025, Japan.

PMID: 26285862 DOI: 10.1021/jz2016044

Abstract

We used a cell-sized model system, giant liposomes, to investigate the interaction between lipid membranes and surfactants, and the membrane transformation during the solubilization process was captured in real time. We found that there are four distinct dynamics in surfactant-induced membrane deformation: an episodic increase in the membrane area prior to pore-forming associated shrinkage (Dynamics A), fission into many small liposomes (Dynamics B), the formation of multilamellar vesicles and peeling (Dynamics C), and bursting (Dynamics D). Classification of the diversity of membrane dynamics may contribute to a better understanding of the physicochemical mechanism of membrane solubilization induced by various surfactants.

Keywords: cell-sized liposome; detergent; lipid bilayer; membrane pore; morphological change; solubilization; surfactant

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