Display options
Cite
Wojnarowska Z, Roland CM, Kolodziejczyk K, et al. Quantifying the Structural Dynamics of Pharmaceuticals in the Glassy State. J Phys Chem Lett. 2012;3(10):1238-41doi: 10.1021/jz300349a.
Wojnarowska, Z., Roland, C. M., Kolodziejczyk, K., Swiety-Pospiech, A., Grzybowska, K., & Paluch, M. (2012). Quantifying the Structural Dynamics of Pharmaceuticals in the Glassy State. The journal of physical chemistry letters, 3(10), 1238-41. https://doi.org/10.1021/jz300349a
Wojnarowska, Z, et al. "Quantifying the Structural Dynamics of Pharmaceuticals in the Glassy State." The journal of physical chemistry letters vol. 3,10 (2012): 1238-41. doi: https://doi.org/10.1021/jz300349a
Wojnarowska Z, Roland CM, Kolodziejczyk K, Swiety-Pospiech A, Grzybowska K, Paluch M. Quantifying the Structural Dynamics of Pharmaceuticals in the Glassy State. J Phys Chem Lett. 2012 May 17;3(10):1238-41. doi: 10.1021/jz300349a. Epub 2012 Apr 27. PMID: 26286764.
Copy Download .nbib Format: NLM
Share it on

J Phys Chem Lett. 2012 May 17;3(10):1238-41. doi: 10.1021/jz300349a. Epub 2012 Apr 27.

Quantifying the Structural Dynamics of Pharmaceuticals in the Glassy State.

The journal of physical chemistry letters

Z Wojnarowska, C M Roland, K Kolodziejczyk, A Swiety-Pospiech, K Grzybowska, M Paluch

Affiliations

  1. †Institute of Physics, Silesian University, ul. Uniwersytecka 4, 40-007 Katowice, Poland.
  2. ‡Chemistry Division, Naval Research Laboratory, Code 6120, Washington, DC 20375-5342, United States.

PMID: 26286764 DOI: 10.1021/jz300349a

Abstract

Structural dynamics in the glassy state of two protic ionic liquids, carvedilol phosphate and procaine hydrochloride, were characterized from analysis of changes in the conductivity relaxation times during physical aging. The obtained relaxation times, having a magnitude exceeding feasible experimental time scales and thus not directly measurable, are consistent with published data from a method that relies on the presence of a secondary relaxation. We also observe a narrowing of the relaxation dispersion, specific to higher frequencies, that is a consequence of the heterogeneous dynamics of deeply supercooled materials.

Keywords: amorphous pharmaceuticals; heterogeneous dynamics; ionic conductivity; physical aging; protic ionic liquid

Publication Types