Display options
Cite
Bajaj S, Dusza SW, Marchetti MA, et al. Growth-Curve Modeling of Nevi With a Peripheral Globular Pattern. JAMA Dermatol. 2015;151(12):1338-1345doi: 10.1001/jamadermatol.2015.2231.
Bajaj, S., Dusza, S. W., Marchetti, M. A., Wu, X., Fonseca, M., Kose, K., Brito, J., Carrera, C., Martins de Silva, V. P., Malvehy, J., Puig, S., Yagerman, S., Liebman, T. N., Scope, A., Halpern, A. C., & Marghoob, A. A. (2015). Growth-Curve Modeling of Nevi With a Peripheral Globular Pattern. JAMA dermatology, 151(12), 1338-1345. https://doi.org/10.1001/jamadermatol.2015.2231
Bajaj, Shirin, et al. "Growth-Curve Modeling of Nevi With a Peripheral Globular Pattern." JAMA dermatology vol. 151,12 (2015): 1338-1345. doi: https://doi.org/10.1001/jamadermatol.2015.2231
Bajaj S, Dusza SW, Marchetti MA, Wu X, Fonseca M, Kose K, Brito J, Carrera C, Martins de Silva VP, Malvehy J, Puig S, Yagerman S, Liebman TN, Scope A, Halpern AC, Marghoob AA. Growth-Curve Modeling of Nevi With a Peripheral Globular Pattern. JAMA Dermatol. 2015 Dec 01;151(12):1338-1345. doi: 10.1001/jamadermatol.2015.2231. PMID: 26287475; PMCID: PMC5483973.
Copy Download .nbib Format: NLM
Share it on

JAMA Dermatol. 2015 Dec 01;151(12):1338-1345. doi: 10.1001/jamadermatol.2015.2231.

Growth-Curve Modeling of Nevi With a Peripheral Globular Pattern.

JAMA dermatology

Shirin Bajaj, Stephen W Dusza, Michael A Marchetti, Xinyuan Wu, Maira Fonseca, Kivanc Kose, Johanna Brito, Cristina Carrera, Vanessa P Martins de Silva, Josep Malvehy, Susana Puig, Sarah Yagerman, Tracey N Liebman, Alon Scope, Allan C Halpern, Ashfaq A Marghoob

Affiliations

  1. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  2. Melanoma Unit, Department of Dermatology, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain3Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, B.
  3. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York4Department of Dermatology, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

PMID: 26287475 PMCID: PMC5483973 DOI: 10.1001/jamadermatol.2015.2231

Abstract

IMPORTANCE: Although nevi with a peripheral rim of globules (peripheral globular nevi [PGN]) observed with dermoscopy are associated with enlarging melanocytic nevi, their actual growth dynamics remain unknown. Because change is a sensitive but nonspecific marker for melanoma, beginning to understand the growth patterns of nevi may improve the ability of physicians to differentiate normal from abnormal growth and reduce unnecessary biopsies.

OBJECTIVE: To study the growth dynamics and morphologic evolution of PGN on dermoscopy.

DESIGN, SETTING, AND PARTICIPANTS: A total of 84 participants with 121 PGN from September 1, 1999, through May 1, 2013, were identified retrospectively. Cohorts were recruited from the Memorial Sloan Kettering Cancer Center; Melanoma Unit of the Hospital Clinic, University of Barcelona; and Study of Nevi in Children. All 3 cohorts underwent longitudinal monitoring with serial dermoscopic imaging of their PGN. Data analysis was performed from May 1, 2014, through April 1, 2015.

MAIN OUTCOMES AND MEASURES: Establishment of the natural growth curve of PGN. The secondary aim was to establish the median time to growth cessation in those PGN for which the size eventually stabilized and/or had begun to decrease during the study period.

RESULTS: The median duration of follow-up was 25.1 (range, 2.0-114.4) months. Most of the nevi (116 [95.9%]) enlarged at some point during sequential monitoring. The rate of increase in the surface area of PGN varied among cohorts and ranged from -0.47 to 2.26 mm2/mo (mean rate, 0.25 [95% CI, 0.14-0.36] mm2/mo). The median time to growth cessation in the 26 PGN that stabilized or decreased in size (21.5%) was 58.6 months. All lesions changed in a symmetric manner and 91 (75.2%) displayed a decrease in the density of peripheral globules over time.

CONCLUSIONS AND RELEVANCE: Nevi displaying a peripheral globular pattern enlarged symmetrically with apparent growth cessation occurring during a span of 4 to 5 years. Our results reiterate the important concept that not all growth is associated with malignancy.

References

  1. J Am Acad Dermatol. 2012 Jul;67(1):e17-27 - PubMed
  2. J Invest Dermatol. 2011 Aug;131(8):1615-21 - PubMed
  3. J Am Acad Dermatol. 2000 Sep;43(3):467-76 - PubMed
  4. Arch Dermatol. 2005 Aug;141(8):998-1006 - PubMed
  5. JAMA Dermatol. 2015 Apr;151(4):447-8 - PubMed
  6. Br J Dermatol. 2009 Dec;161(6):1270-7 - PubMed
  7. J Dtsch Dermatol Ges. 2007 Nov;5(11):985-92 - PubMed
  8. ISRN Dermatol. 2011;2011:642157 - PubMed
  9. Arch Dermatol. 2011 Jun;147(6):663-70 - PubMed
  10. J Sch Health. 2007 Aug;77(6):312-8 - PubMed
  11. Arch Dermatol. 2011 Jun;147(6):731-2 - PubMed
  12. Arch Dermatol. 2004 Jan;140(1):49-56 - PubMed
  13. Br J Dermatol. 2014 Nov;171(5):1060-5 - PubMed
  14. J Invest Dermatol. 2011 Feb;131(2):542-5 - PubMed
  15. J Am Acad Dermatol. 2009 Dec;61(6):1001-13 - PubMed
  16. Semin Cutan Med Surg. 2009 Sep;28(3):149-56 - PubMed
  17. J Invest Dermatol. 2004 Oct;123(4):733-6 - PubMed
  18. Arch Dermatol. 2010 Apr;146(4):459-60 - PubMed
  19. JAMA Dermatol. 2015 May;151(5):489-96 - PubMed
  20. Nature. 2005 Aug 4;436(7051):720-4 - PubMed
  21. Arch Dermatol. 2000 Mar;136(3):316-20 - PubMed

Publication Types

Grant support