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Gao Y, Zhou DS, Hai P, et al. Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla. Nat Prod Bioprospect. 2015;5(5):247-53doi: 10.1007/s13659-015-0074-2.
Gao, Y., Zhou, D. S., Hai, P., Li, Y., & Wang, F. (2015). Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla. Natural products and bioprospecting, 5(5), 247-53. https://doi.org/10.1007/s13659-015-0074-2
Gao, Yuan, et al. "Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla." Natural products and bioprospecting vol. 5,5 (2015): 247-53. doi: https://doi.org/10.1007/s13659-015-0074-2
Gao Y, Zhou DS, Hai P, Li Y, Wang F. Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla. Nat Prod Bioprospect. 2015 Oct;5(5):247-53. doi: 10.1007/s13659-015-0074-2. Epub 2015 Sep 29. PMID: 26416155; PMCID: PMC4607677.
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Nat Prod Bioprospect. 2015 Oct;5(5):247-53. doi: 10.1007/s13659-015-0074-2. Epub 2015 Sep 29.

Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla.

Natural products and bioprospecting

Yuan Gao, Dong-Sheng Zhou, Ping Hai, Yan Li, Fei Wang

Affiliations

  1. BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.
  2. Department of Chemical Engineering, Yibin University, Yibin, 644000, People's Republic of China.
  3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
  4. BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China. [email protected].

PMID: 26416155 PMCID: PMC4607677 DOI: 10.1007/s13659-015-0074-2

Abstract

Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F-H (1, 3, 4), 17-epi-rauvotetraphylline F (2) and 21-epi-rauvotetraphylline H (5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.

Keywords: Monoterpenoid indole alkaloid; Rauvolfia tetraphylla; Rauvotetraphylline

References

  1. J Agric Food Chem. 1975 Sep-Oct;23(5):1010-1 - PubMed
  2. J Immunol Methods. 1983 Dec 16;65(1-2):55-63 - PubMed
  3. Int J Oncol. 2006 Nov;29(5):1065-73 - PubMed
  4. J Nat Prod. 2002 Jul;65(7):1006-10 - PubMed
  5. Phytochemistry. 2015 Jan;109:84-95 - PubMed
  6. J Nat Prod. 2000 Oct;63(10):1456-60 - PubMed
  7. Phytochemistry. 2002 Jun;60(3):315-20 - PubMed

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