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Yang Y, Hwang S, Kim M, et al. Refractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total Thyroidectomy. Endocrinol Metab (Seoul). 2015;30(4):620-5doi: 10.3803/EnM.2015.30.4.620.
Yang, Y., Hwang, S., Kim, M., Lim, Y., Kim, M. H., Lee, S., Lim, D. J., Kang, M. I., & Cha, B. Y. (2015). Refractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total Thyroidectomy. Endocrinology and metabolism (Seoul, Korea), 30(4), 620-5. https://doi.org/10.3803/EnM.2015.30.4.620
Yang, Yeoree, et al. "Refractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total Thyroidectomy." Endocrinology and metabolism (Seoul, Korea) vol. 30,4 (2015): 620-5. doi: https://doi.org/10.3803/EnM.2015.30.4.620
Yang Y, Hwang S, Kim M, Lim Y, Kim MH, Lee S, Lim DJ, Kang MI, Cha BY. Refractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total Thyroidectomy. Endocrinol Metab (Seoul). 2015 Dec;30(4):620-5. doi: 10.3803/EnM.2015.30.4.620. Epub 2015 Sep 22. PMID: 26394731; PMCID: PMC4722420.
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Endocrinol Metab (Seoul). 2015 Dec;30(4):620-5. doi: 10.3803/EnM.2015.30.4.620. Epub 2015 Sep 22.

Refractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total Thyroidectomy.

Endocrinology and metabolism (Seoul, Korea)

Yeoree Yang, Seawon Hwang, Minji Kim, Yejee Lim, Min Hee Kim, Sohee Lee, Dong Jun Lim, Moo Il Kang, Bong Yun Cha

Affiliations

  1. Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  2. Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  3. Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. [email protected].

PMID: 26394731 PMCID: PMC4722420 DOI: 10.3803/EnM.2015.30.4.620

Abstract

The three major forms of treatment for Graves thyrotoxicosis are antithyroid drugs, radioactive iodine therapy and thyroidectomy. Surgery is the definitive treatment for Graves thyrotoxicosis that is generally recommended when other treatments have failed or are contraindicated. Generally, thyrotoxic patients should be euthyroid before surgery to minimize potential complications which usually requires preoperative management with thionamides or inorganic iodine. But several cases of refractory Graves' disease have shown resistance to conventional treatment. Here we report a 40-year-old female patient with Graves' disease who complained of thyrotoxic symptoms for 7 months. Her thyroid function test and thyroid autoantibody profiles were consistent with Graves' disease. One kind of thionamides and β-blocker were started to control her disease. However, she was resistant to nearly all conventional medical therapies, including β-blockers, inorganic iodine, and two thionamides. She experienced hepatotoxicity from the thionamides. What was worse is her past history of serious allergic reaction to corticosteroids, which are often used to help control symptoms. A 2-week regimen of high-dose cholestyramine improved her uncontrolled thyrotoxicosis and subsequent thyroidectomy was successfully performed. In conclusion, cholestyramine could be administered as an effective and safe adjunctive agent for preoperative preparation in patients with severe hyperthyroid Graves's disease that is resistant to conventional therapies.

Keywords: Cholestyramine resin; Drug resistance; Graves disease

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