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Breisig H, Wessling M. Droplet formation and shrinking in aqueous two-phase systems using a membrane emulsification method. Biomicrofluidics. 2015;9(4):044122doi: 10.1063/1.4929519.
Breisig, H., & Wessling, M. (2015). Droplet formation and shrinking in aqueous two-phase systems using a membrane emulsification method. Biomicrofluidics, 9(4), 044122. https://doi.org/10.1063/1.4929519
Breisig, Hans, and Wessling, Matthias. "Droplet formation and shrinking in aqueous two-phase systems using a membrane emulsification method." Biomicrofluidics vol. 9,4 (2015): 044122. doi: https://doi.org/10.1063/1.4929519
Breisig H, Wessling M. Droplet formation and shrinking in aqueous two-phase systems using a membrane emulsification method. Biomicrofluidics. 2015 Aug 24;9(4):044122. doi: 10.1063/1.4929519. eCollection 2015 Jul. PMID: 26339321; PMCID: PMC4552692.
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Biomicrofluidics. 2015 Aug 24;9(4):044122. doi: 10.1063/1.4929519. eCollection 2015 Jul.

Droplet formation and shrinking in aqueous two-phase systems using a membrane emulsification method.

Biomicrofluidics

Hans Breisig, Matthias Wessling

PMID: 26339321 PMCID: PMC4552692 DOI: 10.1063/1.4929519

Abstract

Using a membrane emulsification method based on porous hollow-fiber membranes in combination with an aqueous two-phase system (ATPS), we are able to produce "water-in-water" droplets with narrow-dispersed size distributions. The equilibrium phases of the aqueous two-phase system polyethylene glycol-dipotassium hydrogen phosphate are used for this purpose. The droplet diameter of a given fluid system is determined by the flow rates of the continuous and disperse phase as well as the hollow fiber dimensions. When diluting the disperse phase and thus moving the ATPS system out of equilibrium, the droplet size can be further reduced in comparison to the equilibrium case. Generally, droplets formed with this method have diameters 20%-60% larger than the inner hollow fiber diameter. The new strategy of diluting the disperse phase allows the production of droplet diameter below the inner diameter of the membrane.

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