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Bose N, Zhang X, Maiti TK, et al. The role of acoustofluidics in targeted drug delivery. Biomicrofluidics. 2015;9(5):052609doi: 10.1063/1.4928947.
Bose, N., Zhang, X., Maiti, T. K., & Chakraborty, S. (2015). The role of acoustofluidics in targeted drug delivery. Biomicrofluidics, 9(5), 052609. https://doi.org/10.1063/1.4928947
Bose, Nilanjana, et al. "The role of acoustofluidics in targeted drug delivery." Biomicrofluidics vol. 9,5 (2015): 052609. doi: https://doi.org/10.1063/1.4928947
Bose N, Zhang X, Maiti TK, Chakraborty S. The role of acoustofluidics in targeted drug delivery. Biomicrofluidics. 2015 Aug 20;9(5):052609. doi: 10.1063/1.4928947. eCollection 2015 Sep. PMID: 26339329; PMCID: PMC4545083.
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Biomicrofluidics. 2015 Aug 20;9(5):052609. doi: 10.1063/1.4928947. eCollection 2015 Sep.

The role of acoustofluidics in targeted drug delivery.

Biomicrofluidics

Nilanjana Bose, Xunli Zhang, Tapas K Maiti, Suman Chakraborty

Affiliations

  1. Department of Biotechnology, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.
  2. Bioengineering Group, Engineering Sciences, University of Southampton , Southampton SO17 1BJ, United Kingdom.
  3. Department of Mechanical Engineering, Indian Institute of Technology Kharagpur , Kharagpur 721302, India.

PMID: 26339329 PMCID: PMC4545083 DOI: 10.1063/1.4928947

Abstract

With the fast development of acoustic systems in clinical and therapeutic applications, acoustically driven microbubbles have gained a prominent role as powerful tools to carry, transfer, direct, and target drug molecules in cells, tissues, and tumors in the expanding fields of targeted drug delivery and gene therapy. The aim of the present study is to establish a biocompatible acoustic microfluidic system and to demonstrate the generation of an acoustic field and its effects on microbubbles and biological cells in the microfluidic system. The acoustic field creates non-linear oscillations of the microbubble-clusters, which results in generation of shear stress on cells in such microsystems. This effectively helps in delivering extracellular probes in living cells by sonoporation. The sonoporation is investigated under the combined effects of acoustic stress and hydrodynamic stress during targeted drug and gene delivery.

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