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Enkhmaa B, Anuurad E, Zhang W, et al. Lipoprotein(a) and apolipoprotein(a) in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2015;84(2):229-235doi: 10.1111/cen.12937.
Enkhmaa, B., Anuurad, E., Zhang, W., Abbuthalha, A., Kaur, P., Visla, J., Karakas, S., & Berglund, L. (2016). Lipoprotein(a) and apolipoprotein(a) in polycystic ovary syndrome. Clinical endocrinology, 84(2), 229-235. https://doi.org/10.1111/cen.12937
Enkhmaa, Byambaa, et al. "Lipoprotein(a) and apolipoprotein(a) in polycystic ovary syndrome." Clinical endocrinology vol. 84,2 (2016): 229-235. doi: https://doi.org/10.1111/cen.12937
Enkhmaa B, Anuurad E, Zhang W, Abbuthalha A, Kaur P, Visla J, Karakas S, Berglund L. Lipoprotein(a) and apolipoprotein(a) in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2016 Feb;84(2):229-235. doi: 10.1111/cen.12937. Epub 2015 Oct 05. PMID: 26341109; PMCID: PMC4779071.
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Clin Endocrinol (Oxf). 2016 Feb;84(2):229-235. doi: 10.1111/cen.12937. Epub 2015 Oct 05.

Lipoprotein(a) and apolipoprotein(a) in polycystic ovary syndrome.

Clinical endocrinology

Byambaa Enkhmaa, Erdembileg Anuurad, Wei Zhang, Adnan Abbuthalha, Parneet Kaur, Jasmeen Visla, Sidika Karakas, Lars Berglund

Affiliations

  1. Department of Internal Medicine, School of Medicine, University of California, Davis, CA, USA.
  2. The Department of Veterans Affairs, Northern California Health Care System, Sacramento, CA, USA.

PMID: 26341109 PMCID: PMC4779071 DOI: 10.1111/cen.12937

Abstract

OBJECTIVE: Levels of lipoprotein(a), Lp(a), an independent risk factor for cardiovascular disease (CVD), are affected by sex hormones. Women with polycystic ovary syndrome (PCOS) have elevated androgen levels and are at increased CVD risk. We investigated the impact of PCOS-related hormonal imbalance on Lp(a) levels in relation to apo(a) gene size polymorphism, a major regulator of Lp(a) level.

DESIGN: Cross-sectional.

PATIENTS: Forty-one Caucasian women with PCOS based on the NIH criteria.

MEASUREMENTS: (1) Apo(a) gene size polymorphism measured as Kringle (K) 4 repeat number; (2) total plasma Lp(a) level; (3) allele-specific apo(a) level assessing the amount of Lp(a) carried by an individual apo(a) allele/isoform; and (4) sex hormone levels.

RESULTS: The mean age was 32 ± 6 years, and the mean BMI was 35 ± 8 with 66% of women classified as obese (BMI >30 kg/m

CONCLUSIONS: The apo(a) genetic variability remains the major regulator of plasma Lp(a) levels in women with PCOS.

© 2015 John Wiley & Sons Ltd.

References

  1. Clin Chem. 1972 Jun;18(6):499-502 - PubMed
  2. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):387-92 - PubMed
  3. J Lipid Res. 2002 Feb;43(2):234-44 - PubMed
  4. Circulation. 1993 Apr;87(4):1135-41 - PubMed
  5. Nature. 1987 Nov 12-18;330(6144):132-7 - PubMed
  6. Breast Cancer Res Treat. 2012 Dec;136(3):769-76 - PubMed
  7. J Intern Med. 2013 Jan;273(1):6-30 - PubMed
  8. J Am Coll Cardiol. 2014 Feb 11;63(5):470-7 - PubMed
  9. Arch Intern Med. 1996 Apr 22;156(8):866-72 - PubMed
  10. Transl Res. 2011 Aug;158(2):92-8 - PubMed
  11. Arterioscler Thromb Vasc Biol. 2000 Dec;20(12):2619-24 - PubMed
  12. Circulation. 2008 Jan 15;117(2):176-84 - PubMed
  13. J Clin Endocrinol Metab. 2008 Apr;93(4):1482-8 - PubMed
  14. J Clin Endocrinol Metab. 1996 Jul;81(7):2633-7 - PubMed
  15. Diabet Med. 2005 Mar;22(3):306-11 - PubMed
  16. Horm Metab Res. 2006 Sep;38(9):581-6 - PubMed
  17. J Clin Invest. 1992 Apr;89(4):1166-71 - PubMed
  18. Hum Mol Genet. 1993 Apr;2(4):361-6 - PubMed
  19. Mol Cell Biochem. 2000 Apr;207(1-2):149-55 - PubMed
  20. Hum Genet. 1991 Apr;86(6):607-14 - PubMed
  21. J Clin Endocrinol Metab. 2010 May;95(5):2038-49 - PubMed
  22. JAMA. 2009 Jul 22;302(4):412-23 - PubMed
  23. Hum Mol Genet. 1993 Jul;2(7):933-40 - PubMed
  24. Fertil Steril. 2007 Jun;87(6):1363-8 - PubMed
  25. Eur Heart J. 2010 Dec;31(23):2844-53 - PubMed
  26. Diabetes Obes Metab. 2006 Sep;8(5):538-54 - PubMed
  27. Gynecol Endocrinol. 2005 May;20(5):258-63 - PubMed
  28. J Am Coll Cardiol. 2010 May 11;55(19):2160-7 - PubMed
  29. Hum Reprod Update. 2011 Nov-Dec;17 (6):741-60 - PubMed
  30. JAMA. 2009 Jun 10;301(22):2331-9 - PubMed
  31. Atherosclerosis. 2010 Aug;211(2):526-30 - PubMed
  32. J Am Coll Cardiol. 2008 Jul 8;52(2):124-31 - PubMed
  33. Clin Endocrinol (Oxf). 2007 Dec;67(6):904-8 - PubMed
  34. Int J Clin Pract. 2009 Jan;63(1):56-62 - PubMed
  35. Prev Med. 1994 May;23(3):345-53 - PubMed
  36. Gynecol Obstet Invest. 2009;68(1):33-9 - PubMed
  37. Hum Reprod. 2009 Sep;24(9):2286-92 - PubMed

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