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Zong Q, Ni D, Li L, et al. Association of rs731236 polymorphism in the vitamin D receptor gene with degenerative disc disease: evidence from a meta-analysis. Int J Clin Exp Med. 2015;8(6):10178-86
Zong, Q., Ni, D., Li, L., & Shi, Y. (2015). Association of rs731236 polymorphism in the vitamin D receptor gene with degenerative disc disease: evidence from a meta-analysis. International journal of clinical and experimental medicine, 8(6), 10178-86.
Zong, Qiang, et al. "Association of rs731236 polymorphism in the vitamin D receptor gene with degenerative disc disease: evidence from a meta-analysis." International journal of clinical and experimental medicine vol. 8,6 (2015): 10178-86.
Zong Q, Ni D, Li L, Shi Y. Association of rs731236 polymorphism in the vitamin D receptor gene with degenerative disc disease: evidence from a meta-analysis. Int J Clin Exp Med. 2015 Jun 15;8(6):10178-86. eCollection 2015. PMID: 26309717; PMCID: PMC4538068.
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Int J Clin Exp Med. 2015 Jun 15;8(6):10178-86. eCollection 2015.

Association of rs731236 polymorphism in the vitamin D receptor gene with degenerative disc disease: evidence from a meta-analysis.

International journal of clinical and experimental medicine

Qiang Zong, Dongkui Ni, Lijun Li, Yubo Shi

Affiliations

  1. Department of Orthopaedics, The Second Hospital of Tianjin Medical University Tianjin, China.

PMID: 26309717 PMCID: PMC4538068

Abstract

The purpose of this study was to investigate the association between the rs731236 polymorphism in the vitamin D receptor gene and degenerative disc disease, especially in Chinese. We elaborately searched the relevant studies through China National Knowledge Infrastructure (CNKI), PubMed and EMBASE databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the association. A total of 10 studies involving 1,220 cases and 1,225 controls were included in the present study. Overall, no evidence of significant risk between rs731236 polymorphism and degenerative disc disease was found in any genetic models. In addition, stratified analyses by ethnicity revealed similar results. However, stratified analyses by sample size in Chinese population show that sample size may be the primary source of heterogeneity. This meta-analysis suggested that the rs731236 polymorphism may not be associated with degenerative disc disease. However, for Asians, there existed some diversities, especially in Chinese population. Therefore, a large number of well-designed studies are still required to assess this polymorphism and degenerative disc disease.

Keywords: Degenerative disc disease; gene; meta-analysis; polymorphism; rs731236; vitamin D receptor

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