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Yamada S, Morine Y, Imura S, et al. Liver regeneration after splenectomy in patients with liver cirrhosis. Hepatol Res. 2015;46(5):443-9doi: 10.1111/hepr.12573.
Yamada, S., Morine, Y., Imura, S., Ikemoto, T., Arakawa, Y., Iwahashi, S., Saito, Y., Yoshikawa, M., Teraoku, H., & Shimada, M. (2016). Liver regeneration after splenectomy in patients with liver cirrhosis. Hepatology research : the official journal of the Japan Society of Hepatology, 46(5), 443-9. https://doi.org/10.1111/hepr.12573
Yamada, Shinichiro, et al. "Liver regeneration after splenectomy in patients with liver cirrhosis." Hepatology research : the official journal of the Japan Society of Hepatology vol. 46,5 (2016): 443-9. doi: https://doi.org/10.1111/hepr.12573
Yamada S, Morine Y, Imura S, Ikemoto T, Arakawa Y, Iwahashi S, Saito Y, Yoshikawa M, Teraoku H, Shimada M. Liver regeneration after splenectomy in patients with liver cirrhosis. Hepatol Res. 2016 Mar;46(5):443-9. doi: 10.1111/hepr.12573. Epub 2015 Oct 02. PMID: 26428414.
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Hepatol Res. 2016 Mar;46(5):443-9. doi: 10.1111/hepr.12573. Epub 2015 Oct 02.

Liver regeneration after splenectomy in patients with liver cirrhosis.

Hepatology research : the official journal of the Japan Society of Hepatology

Shinichiro Yamada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Yu Saito, Masato Yoshikawa, Hiroki Teraoku, Mitsuo Shimada

Affiliations

  1. Department of Surgery, The University of Tokushima, Tokushima City, Japan.

PMID: 26428414 DOI: 10.1111/hepr.12573

Abstract

AIM: Splenectomy is a well-known procedure to improve thrombocytopenia and liver function in patients with liver cirrhosis (LC). However, the effect of splenectomy on liver regeneration remains unclear. The aim of this study is to investigate the effect of splenectomy on liver regeneration.

METHODS: Twenty patients with LC who underwent splenectomy were included in this study. Liver and splenic volumes were measured by a 3-D simulation imaging system. Liver volume (LV) and clinicopathological data were compared before and 6 months after splenectomy. Thereafter, patients were divided into two groups: the elevated LV group and the reduced LV group. Patient characteristics were compared between the two groups.

RESULTS: Postoperative LV was increased in 14 patients compared with the preoperative state. Thrombocytopenia, leukopenia, total bilirubin and prothrombin time were improved after splenectomy. In the elevated LV group, four patients exhibited improved Child-Pugh grades after splenectomy, whereas no patients demonstrated improvement in the reduced LV group. The elevated LV group exhibited high albumin level, good indocyanine green retention rate at 15 min and large splenic volume compared with the same measurements in the decreased group. Patients with larger spleen volumes and higher albumin values before splenectomy showed increased rates of LV after splenectomy.

CONCLUSION: Splenectomy for patients with LC improved pancytopenia and liver function. Especially, in patients with large spleen and high albumin levels, considerable increases in LV and improved liver function were observed.

© 2015 The Japan Society of Hepatology.

Keywords: liver cirrhosis; liver regeneration; splenectomy

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