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Johnston RJ, Yu X, Grogan JL. The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8. Oncoimmunology. 2015;4(9):e1036214doi: 10.1080/2162402X.2015.1036214.
Johnston, R. J., Yu, X., & Grogan, J. L. (2015). The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8. Oncoimmunology, 4(9), e1036214. https://doi.org/10.1080/2162402X.2015.1036214
Johnston, Robert J, et al. "The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8." Oncoimmunology vol. 4,9 (2015): e1036214. doi: https://doi.org/10.1080/2162402X.2015.1036214
Johnston RJ, Yu X, Grogan JL. The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8. Oncoimmunology. 2015 May 27;4(9):e1036214. doi: 10.1080/2162402X.2015.1036214. eCollection 2015 Sep. PMID: 26405604; PMCID: PMC4570113.
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Oncoimmunology. 2015 May 27;4(9):e1036214. doi: 10.1080/2162402X.2015.1036214. eCollection 2015 Sep.

The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8.

Oncoimmunology

Robert J Johnston, Xin Yu, Jane L Grogan

Affiliations

  1. Department of Cancer Immunology; Genentech ; South San Francisco, CA, USA.

PMID: 26405604 PMCID: PMC4570113 DOI: 10.1080/2162402X.2015.1036214

Abstract

Success in eliciting tumor rejection by therapeutic blockade of T cell checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has spurred re-evaluation of additional receptors that regulate antitumor responses. Here we summarize our recent studies characterizing the role of co-inhibitory receptor TIGIT in antitumor and other chronic CD8

Keywords: CD226; PD1; TIGIT; antibodies; cancer immunotherapy; virus

References

  1. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5399-404 - PubMed
  2. J Biol Chem. 2014 Jun 20;289(25):17647-57 - PubMed
  3. J Immunol. 2012 Apr 15;188(8):3869-75 - PubMed
  4. Nat Immunol. 2009 Jan;10(1):48-57 - PubMed
  5. Eur J Immunol. 2011 Apr;41(4):902-15 - PubMed
  6. Nature. 2006 Feb 9;439(7077):682-7 - PubMed
  7. Immunity. 2014 Apr 17;40(4):569-81 - PubMed
  8. Cancer Cell. 2014 Dec 8;26(6):923-37 - PubMed
  9. Nat Immunol. 2005 Dec;6(12 ):1245-52 - PubMed
  10. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17858-63 - PubMed

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