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Showing 1 to 12 of 119 entries
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The law and politics of workplace wellness. Editor's note.

Journal of health politics, policy and law

Grogan CM.
PMID: 25436271
J Health Polit Policy Law. 2014 Oct;39(5):955-6.

No abstract available.

The orthotic treatment of stable ankle fractures.

Orthopedics

Polakoff DR, Pearce SM, Grogan DP, Burkhead WZ.
PMID: 24822972
Orthopedics. 1984 Nov;7(11):1712-5. doi: 10.3928/0147-7447-19841101-10.

Fifteen limbs with stable lateral malleolar fractures treated with an adjustable, functional orthosis were compared to 12 limbs managed with short leg walking casts. The limbs managed with the adjustable orthosis were clinically healed at an average of 3.3...

Planarizing technique for ion-beam polishing of diamond films.

Applied optics

Grogan DF, Zhao T, Bovard BG, Macleod HA.
PMID: 20720781
Appl Opt. 1992 Apr 01;31(10):1483-7. doi: 10.1364/AO.31.001483.

Diamond films, deposited on silicon substrates through microwave-assisted chemical vapor deposition, have been polished with a 500-eV beam of oxygen ions through the use of a planarizing layer. The films' surface roughness, in excess of 1 microm (rms) and...

The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8.

Oncoimmunology

Johnston RJ, Yu X, Grogan JL.
PMID: 26405604
Oncoimmunology. 2015 May 27;4(9):e1036214. doi: 10.1080/2162402X.2015.1036214. eCollection 2015 Sep.

Success in eliciting tumor rejection by therapeutic blockade of T cell checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has spurred re-evaluation of additional receptors that regulate antitumor responses. Here we summarize our recent studies characterizing the role of co-inhibitory...

ATTR Amyloidosis: Current and Emerging Management Strategies: .

JACC. CardioOncology

Griffin JM, Rosenthal JL, Grodin JL, Maurer MS, Grogan M, Cheng RK.
PMID: 34729521
JACC CardioOncol. 2021 Oct 19;3(4):488-505. doi: 10.1016/j.jaccao.2021.06.006. eCollection 2021 Oct.

Transthyretin cardiac amyloidosis (ATTR-CA) is increasingly diagnosed owing to the emergence of noninvasive imaging and improved awareness. Clinical penetrance of pathogenic alleles is not complete and therefore there is a large cohort of asymptomatic transthyretin variant carriers. Screening strategies,...

Phase Ib Trial of Copanlisib, A Phosphoinositide-3 Kinase (PI3K) Inhibitor, with Trastuzumab in Advanced Pre-Treated HER2-Positive Breast Cancer "PantHER".

Cancers

Keegan NM, Furney SJ, Walshe JM, Gullo G, Kennedy MJ, Smith D, McCaffrey J, Kelly CM, Egan K, Kerr J, Given M, O'Donovan P, Hernando A, Teiserskiene A, Parker I, Kay E, Farrelly A, Carr A, Calzaferri G, McDermott R, Keane MM, Grogan L, Breathnach O, Morris PG, Toomey S, Hennessy BT.
PMID: 33799597
Cancers (Basel). 2021 Mar 11;13(6). doi: 10.3390/cancers13061225.

BACKGROUND: Activation of the phosphoinositide-3 kinase (PI3K) pathway is a resistance mechanism to anti-human epidermal growth factor receptor 2 (HER2) therapy. This phase Ib trial was conducted to determine the maximum tolerated dose (MTD) of copanlisib, an intravenous (IV)...

Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.

Nature medicine

Yuen KC, Liu LF, Gupta V, Madireddi S, Keerthivasan S, Li C, Rishipathak D, Williams P, Kadel EE, Koeppen H, Chen YJ, Modrusan Z, Grogan JL, Banchereau R, Leng N, Thastrom A, Shen X, Hashimoto K, Tayama D, van der Heijden MS, Rosenberg JE, McDermott DF, Powles T, Hegde PS, Huseni MA, Mariathasan S.
PMID: 33547461
Nat Med. 2021 Mar;27(3):560. doi: 10.1038/s41591-021-01246-4.

No abstract available.

Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (.

Antioxidants (Basel, Switzerland)

Boiangiu RS, Mihasan M, Gorgan DL, Stache BA, Hritcu L.
PMID: 33535660
Antioxidants (Basel). 2021 Feb 01;10(2). doi: 10.3390/antiox10020212.

Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess cognitive-improving abilities and antioxidant properties in different rodent models of Alzheimer's disease (AD), eluding the side-effects of nicotine (NIC), the parent molecule. In the current study, we evaluated...

Investigation of polyethylene terephthalate (PET) drinking bottles as marine reservoirs for fecal bacteria and phytoplankton.

Marine pollution bulletin

Grogan AE, Mallin MA, Cahoon LB.
PMID: 34872168
Mar Pollut Bull. 2021 Dec;173:113052. doi: 10.1016/j.marpolbul.2021.113052. Epub 2021 Oct 28.

Polyethylene terephthalate (PET) is frequently used in the food and beverage industry and therefore contributes greatly to plastic marine debris. The fecal pollution indicator bacteria Enterococcus is used for marine water contamination assessments and is regularly found in storm...

Clinical Implications of the Amyloidogenic V122I Transthyretin Variant in the General Population.

Journal of cardiac failure

Kozlitina J, Garg S, Drazner MH, Matulevicius SA, Ayers C, Overton J, Reid J, Baras A, Rao K, Pandey A, Berry J, de Lemos JA, Grodin JL.
PMID: 34634447
J Card Fail. 2021 Oct 09; doi: 10.1016/j.cardfail.2021.09.015. Epub 2021 Oct 09.

BACKGROUND: The V122I variant in transthyretin (TTR) is the most common amyloidogenic mutation worldwide. The aim of this study is to describe the cardiac phenotype and risk for adverse cardiovascular outcomes of young V122I TTR carriers in the general...

COVID-19-related mortality in cancer patients in an Irish setting.

Irish journal of medical science

Linehan A, Fitzpatrick O, Cowzer D, Hennessy MA, Coyne ZL, Nolan A, Clarke M, Dhonaill RN, Hennessy BT, Morris PG, Grogan L, Breathnach O.
PMID: 34697787
Ir J Med Sci. 2021 Oct 25; doi: 10.1007/s11845-021-02815-9. Epub 2021 Oct 25.

BACKGROUND: The COVID-19 pandemic has impacted significantly on healthcare across the globe. It has been reported to have higher incidence and be associated with worse outcomes in patients with cancer.AIM: To examine the characteristics of patients with cancer who...

ATTR Amyloidosis: Current and Emerging Management Strategies: .

JACC. CardioOncology

Griffin JM, Rosenthal JL, Grodin JL, Maurer MS, Grogan M, Cheng RK.
PMID: 34729521
JACC CardioOncol. 2021 Oct 19;3(4):488-505. doi: 10.1016/j.jaccao.2021.06.006. eCollection 2021 Oct.

Transthyretin cardiac amyloidosis (ATTR-CA) is increasingly diagnosed owing to the emergence of noninvasive imaging and improved awareness. Clinical penetrance of pathogenic alleles is not complete and therefore there is a large cohort of asymptomatic transthyretin variant carriers. Screening strategies,...

Showing 1 to 12 of 119 entries