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Adjobo-Hermans MJ, Cluitmans JC, Bosman GJ. Neuroacanthocytosis: Observations, Theories and Perspectives on the Origin and Significance of Acanthocytes. Tremor Other Hyperkinet Mov (N Y). 2015;5:328doi: 10.7916/D8VH5N2M.
Adjobo-Hermans, M. J., Cluitmans, J. C., & Bosman, G. J. (2015). Neuroacanthocytosis: Observations, Theories and Perspectives on the Origin and Significance of Acanthocytes. Tremor and other hyperkinetic movements (New York, N.Y.), 5328. https://doi.org/10.7916/D8VH5N2M
Adjobo-Hermans, Merel J W, et al. "Neuroacanthocytosis: Observations, Theories and Perspectives on the Origin and Significance of Acanthocytes." Tremor and other hyperkinetic movements (New York, N.Y.) vol. 5 (2015): 328. doi: https://doi.org/10.7916/D8VH5N2M
Adjobo-Hermans MJ, Cluitmans JC, Bosman GJ. Neuroacanthocytosis: Observations, Theories and Perspectives on the Origin and Significance of Acanthocytes. Tremor Other Hyperkinet Mov (N Y). 2015 Aug 25;5:328. doi: 10.7916/D8VH5N2M. eCollection 2015. PMID: 26317043; PMCID: PMC4548760.
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Tremor Other Hyperkinet Mov (N Y). 2015 Aug 25;5:328. doi: 10.7916/D8VH5N2M. eCollection 2015.

Neuroacanthocytosis: Observations, Theories and Perspectives on the Origin and Significance of Acanthocytes.

Tremor and other hyperkinetic movements (New York, N.Y.)

Merel J W Adjobo-Hermans, Judith C A Cluitmans, Giel J C G M Bosman

Affiliations

  1. Department of Biochemistry, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

PMID: 26317043 PMCID: PMC4548760 DOI: 10.7916/D8VH5N2M

Abstract

The presence of acanthocytes in the blood is characteristic of patients suffering from neuroacanthocytosis (NA). Recent studies have described abnormal phosphorylation of the proteins involved in connecting the membrane and cytoskeleton in patient-derived erythrocytes. The involvement of lipids in the underlying signaling pathways and recent reports on in vitro disease-associated lipid alterations support renewed research into lipid composition, signal transduction, and metabolism in patient erythrocytes. In addition to morphology, changes in membrane organization affect erythrocyte function and survival. Patient erythrocytes may have a decreased ability to deform, and this may contribute to accelerated erythrocyte removal and a decreased oxygen supply, especially in vulnerable brain regions. The presently available data indicate that acanthocytes are likely to originate in the bone marrow, making erythropoiesis an obvious new focus in NA research. Moreover, new, detailed morphological observations indicate that acanthocytes may be the tip of the iceberg with regard to misshapen erythrocytes in the circulation of patients with NA. A systematic assessment of patient erythrocyte morphology, deformability, oxygen delivery, and metabolism will be instrumental in determining the putative contribution of erythrocyte function to NA clinical symptoms.

Keywords: Acanthocytosis; erythrocytes; membrane; neurodegeneration; signaling

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