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Chevalier MF, Bobisse S, Costa-Nunes C, et al. High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools. Oncoimmunology. 2015;4(10):e1029702doi: 10.1080/2162402X.2015.1029702.
Chevalier, M. F., Bobisse, S., Costa-Nunes, C., Cesson, V., Jichlinski, P., Speiser, D. E., Harari, A., Coukos, G., Romero, P., Nardelli-Haefliger, D., Jandus, C., & Derré, L. (2015). High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools. Oncoimmunology, 4(10), e1029702. https://doi.org/10.1080/2162402X.2015.1029702
Chevalier, Mathieu F, et al. "High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools." Oncoimmunology vol. 4,10 (2015): e1029702. doi: https://doi.org/10.1080/2162402X.2015.1029702
Chevalier MF, Bobisse S, Costa-Nunes C, Cesson V, Jichlinski P, Speiser DE, Harari A, Coukos G, Romero P, Nardelli-Haefliger D, Jandus C, Derré L. High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools. Oncoimmunology. 2015 May 27;4(10):e1029702. doi: 10.1080/2162402X.2015.1029702. eCollection 2015 Oct. PMID: 26451296; PMCID: PMC4590008.
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Oncoimmunology. 2015 May 27;4(10):e1029702. doi: 10.1080/2162402X.2015.1029702. eCollection 2015 Oct.

High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools.

Oncoimmunology

Mathieu F Chevalier, Sara Bobisse, Carla Costa-Nunes, Valérie Cesson, Patrice Jichlinski, Daniel E Speiser, Alexandre Harari, George Coukos, Pedro Romero, Denise Nardelli-Haefliger, Camilla Jandus, Laurent Derré

Affiliations

  1. Urology Research Unit; Department of Urology; University Hospital of Lausanne (CHUV) ; Lausanne, Switzerland.
  2. Center of Experimental Therapeutics; Department of Oncology; University Hospital of Lausanne ; Lausanne, Switzerland ; Ludwig Center for Cancer Research at University of Lausanne ; Epalinges, Switzerland.
  3. Ludwig Center for Cancer Research at University of Lausanne ; Epalinges, Switzerland.
  4. Ludwig Center for Cancer Research at University of Lausanne ; Epalinges, Switzerland ; Ovarian Cancer Research Center; Perelman School of Medicine; University of Pennsylvania ; Philadelphia, PA USA ; Department of Oncology; University Hospital of Lausanne (CHUV) ; Lausanne, Switzerland.

PMID: 26451296 PMCID: PMC4590008 DOI: 10.1080/2162402X.2015.1029702

Abstract

In immune intervention trials, the comprehensive investigation of immunogenicity or T-cell epitope-mapping is challenging especially when a large set of epitopes needs to be screened and limited sample material is available. To this end, T-cell responses are often monitored using peptide pools. Here, we assessed the magnitude and sensitivity of detection of antigen-specific CD8

Keywords: immune monitoring; peptide pools; tumor-associated antigens; tumor-specific T cells; vaccine trials

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