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1, 2, 3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics

evaluation

Speijer D.
GSID: rBUDBjPhV3oJ
VD Bock, D Speijer, H Hiemstra… - Organic & biomolecular …, 2007 - pubs.rsc.org

Since the discovery of CuI-catalysed click chemistry, the field of peptidomimetics has expanded to include 1,4-connected 1,2,3-triazoles as useful peptide bond isosteres. Here, we report the synthesis of triazole-containing analogues of the naturally occurring tyrosinase inhibitor …

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Bock, V. D., Speijer, D., Hiemstra, H., & van Maarseveen, J. H. (2007). 1, 2, 3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics. Organic & biomolecular chemistry, 5(6), 971-975.
Bock, Victoria D., et al. "1, 2, 3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics." Organic & biomolecular chemistry 5.6 (2007): 971-975.
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Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature.

Case reports in dermatological medicine

Webb KC, Harasimowicz M, Janeczek M, Speiser J, Swan J, Tung R.
PMID: 28424749
Case Rep Dermatol Med. 2017;2017:9359086. doi: 10.1155/2017/9359086. Epub 2017 Mar 23.

Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) used to treat imatinib-resistant chronic myelogenous leukemia (CML), as well as other Philadelphia chromosome-positive lymphoproliferative disorders. While the most commonly reported cutaneous side effects with this therapy include a morbilliform eruption,...

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Webb KC, Harasimowicz M, Janeczek M, et al. Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature. Case Rep Dermatol Med. 2017;2017:9359086doi: 10.1155/2017/9359086.
Webb, K. C., Harasimowicz, M., Janeczek, M., Speiser, J., Swan, J., & Tung, R. (2017). Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature. Case reports in dermatological medicine, 20179359086. https://doi.org/10.1155/2017/9359086
Webb, Kirsten C, et al. "Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature." Case reports in dermatological medicine vol. 2017 (2017): 9359086. doi: https://doi.org/10.1155/2017/9359086
Webb KC, Harasimowicz M, Janeczek M, Speiser J, Swan J, Tung R. Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature. Case Rep Dermatol Med. 2017;2017:9359086. doi: 10.1155/2017/9359086. Epub 2017 Mar 23. PMID: 28424749; PMCID: PMC5382301.
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Mechanistic Aspects of Redox-Induced Assembly and Disassembly of S-Bridged [2M-2S] Structures.

Chemistry (Weinheim an der Bergstrasse, Germany)

Koch F, Berkefeld A, Speiser B, Schubert H.
PMID: 28976037
Chemistry. 2017 Nov 21;23(65):16681-16690. doi: 10.1002/chem.201704599. Epub 2017 Nov 09.

Sulfur-bridged binuclear structures [2M-2S] play a pivotal role in a variety of chemical processes such as bond breaking and formation and electron transfer. In general, structural persistence is deemed essential to the respective function but owing to the lack...

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Koch F, Berkefeld A, Speiser B, et al. Mechanistic Aspects of Redox-Induced Assembly and Disassembly of S-Bridged [2M-2S] Structures. Chemistry. 2017;23(65):16681-16690doi: 10.1002/chem.201704599.
Koch, F., Berkefeld, A., Speiser, B., & Schubert, H. (2017). Mechanistic Aspects of Redox-Induced Assembly and Disassembly of S-Bridged [2M-2S] Structures. Chemistry (Weinheim an der Bergstrasse, Germany), 23(65), 16681-16690. https://doi.org/10.1002/chem.201704599
Koch, Felix, et al. "Mechanistic Aspects of Redox-Induced Assembly and Disassembly of S-Bridged [2M-2S] Structures." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 23,65 (2017): 16681-16690. doi: https://doi.org/10.1002/chem.201704599
Koch F, Berkefeld A, Speiser B, Schubert H. Mechanistic Aspects of Redox-Induced Assembly and Disassembly of S-Bridged [2M-2S] Structures. Chemistry. 2017 Nov 21;23(65):16681-16690. doi: 10.1002/chem.201704599. Epub 2017 Nov 09. PMID: 28976037.
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The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study.

Annals of intensive care

Karvellas CJ, Speiser JL, Tremblay M, Lee WM, Rose CF.
PMID: 28983815
Ann Intensive Care. 2017 Oct 05;7(1):99. doi: 10.1186/s13613-017-0323-0.

BACKGROUND: Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality due to intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty acid-binding protein (FABP7) is a small (15 kDa) cytoplasmic protein abundantly...

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Karvellas CJ, Speiser JL, Tremblay M, et al. The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study. Ann Intensive Care. 2017;7(1):99doi: 10.1186/s13613-017-0323-0.
Karvellas, C. J., Speiser, J. L., Tremblay, M., Lee, W. M., Rose, C. F. (2017). The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study. Annals of intensive care, 7(1), 99. https://doi.org/10.1186/s13613-017-0323-0
Karvellas, Constantine J, et al. "The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study." Annals of intensive care vol. 7,1 (2017): 99. doi: https://doi.org/10.1186/s13613-017-0323-0
Karvellas CJ, Speiser JL, Tremblay M, Lee WM, Rose CF. The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study. Ann Intensive Care. 2017 Oct 05;7(1):99. doi: 10.1186/s13613-017-0323-0. PMID: 28983815; PMCID: PMC5629189.
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High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools.

Oncoimmunology

Chevalier MF, Bobisse S, Costa-Nunes C, Cesson V, Jichlinski P, Speiser DE, Harari A, Coukos G, Romero P, Nardelli-Haefliger D, Jandus C, Derré L.
PMID: 26451296
Oncoimmunology. 2015 May 27;4(10):e1029702. doi: 10.1080/2162402X.2015.1029702. eCollection 2015 Oct.

In immune intervention trials, the comprehensive investigation of immunogenicity or T-cell epitope-mapping is challenging especially when a large set of epitopes needs to be screened and limited sample material is available. To this end, T-cell responses are often monitored...

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Chevalier MF, Bobisse S, Costa-Nunes C, et al. High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools. Oncoimmunology. 2015;4(10):e1029702doi: 10.1080/2162402X.2015.1029702.
Chevalier, M. F., Bobisse, S., Costa-Nunes, C., Cesson, V., Jichlinski, P., Speiser, D. E., Harari, A., Coukos, G., Romero, P., Nardelli-Haefliger, D., Jandus, C., & Derré, L. (2015). High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools. Oncoimmunology, 4(10), e1029702. https://doi.org/10.1080/2162402X.2015.1029702
Chevalier, Mathieu F, et al. "High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools." Oncoimmunology vol. 4,10 (2015): e1029702. doi: https://doi.org/10.1080/2162402X.2015.1029702
Chevalier MF, Bobisse S, Costa-Nunes C, Cesson V, Jichlinski P, Speiser DE, Harari A, Coukos G, Romero P, Nardelli-Haefliger D, Jandus C, Derré L. High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools. Oncoimmunology. 2015 May 27;4(10):e1029702. doi: 10.1080/2162402X.2015.1029702. eCollection 2015 Oct. PMID: 26451296; PMCID: PMC4590008.
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[APROPOS OF TUMOR IMMUNOLOGY. (A MODEL)].

Wiener klinische Wochenschrift

KARRER K, SPEISER P.
PMID: 14325759
Wien Klin Wochenschr. 1964 Nov 27;76:843-4.

No abstract available.

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KARRER K, SPEISER P. ZUR FRAGE DER IMMUNOLOGIE VON TUMOREN. [APROPOS OF TUMOR IMMUNOLOGY. (A MODEL)]. Wien Klin Wochenschr. 1964;76:843-4
KARRER, K., & SPEISER, P. (1964). ZUR FRAGE DER IMMUNOLOGIE VON TUMOREN. [APROPOS OF TUMOR IMMUNOLOGY. (A MODEL)]. Wiener klinische Wochenschrift, 76843-4.
KARRER, K, and SPEISER, P. "ZUR FRAGE DER IMMUNOLOGIE VON TUMOREN." [APROPOS OF TUMOR IMMUNOLOGY. (A MODEL)]. Wiener klinische Wochenschrift vol. 76 (1964): 843-4.
KARRER K, SPEISER P. ZUR FRAGE DER IMMUNOLOGIE VON TUMOREN. [APROPOS OF TUMOR IMMUNOLOGY. (A MODEL)]. Wien Klin Wochenschr. 1964 Nov 27;76:843-4. German. PMID: 14325759.
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A chemically modified platinum electrode as a bidentate diamine ligand for forming well-defined, immobilized bis(eta 1-P-ether phosphane)(diamine)ruthenium(II) complexes.

Angewandte Chemie (International ed. in English)

Novak F, Speiser B, Lindner E, Lu ZL, Mayer HA.
PMID: 15065292
Angew Chem Int Ed Engl. 2004 Apr 02;43(15):2025-8. doi: 10.1002/anie.200353399.

No abstract available.

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Novak F, Speiser B, Lindner E, et al. A chemically modified platinum electrode as a bidentate diamine ligand for forming well-defined, immobilized bis(eta 1-P-ether phosphane)(diamine)ruthenium(II) complexes. Angew Chem Int Ed Engl. 2004;43(15):2025-8doi: 10.1002/anie.200353399.
Novak, F., Speiser, B., Lindner, E., Lu, Z. L., & Mayer, H. A. (2004). A chemically modified platinum electrode as a bidentate diamine ligand for forming well-defined, immobilized bis(eta 1-P-ether phosphane)(diamine)ruthenium(II) complexes. Angewandte Chemie (International ed. in English), 43(15), 2025-8. https://doi.org/10.1002/anie.200353399
Novak, Filip, et al. "A chemically modified platinum electrode as a bidentate diamine ligand for forming well-defined, immobilized bis(eta 1-P-ether phosphane)(diamine)ruthenium(II) complexes." Angewandte Chemie (International ed. in English) vol. 43,15 (2004): 2025-8. doi: https://doi.org/10.1002/anie.200353399
Novak F, Speiser B, Lindner E, Lu ZL, Mayer HA. A chemically modified platinum electrode as a bidentate diamine ligand for forming well-defined, immobilized bis(eta 1-P-ether phosphane)(diamine)ruthenium(II) complexes. Angew Chem Int Ed Engl. 2004 Apr 02;43(15):2025-8. doi: 10.1002/anie.200353399. PMID: 15065292.
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Endometrial cancer: accuracy of the finding of a well differentiated tumor at dilatation and curettage compared to the findings at subsequent hysterectomy.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Obermair A, Geramou M, Gücer F, Denison U, Graf AH, Kapshammer E, Medl M, Rosen A, Wierrani F, Neunteufel W, Frech I, Speiser P, Kainz C, Breitenecker G.
PMID: 11240798
Int J Gynecol Cancer. 1999 Sep;9(5):383-386. doi: 10.1046/j.1525-1438.1999.99050.x.

The objective of this study was to examine the accuracy of the finding of a histologically well differentiated endometrial carcinoma at dilatation and curettage (D & C) prior to hysterectomy. A retrospective multicentric chart review of 137 endometrial cancer...

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Obermair A, Geramou M, Gücer F, et al. Endometrial cancer: accuracy of the finding of a well differentiated tumor at dilatation and curettage compared to the findings at subsequent hysterectomy. Int J Gynecol Cancer. 1999;9(5):383-386doi: 10.1046/j.1525-1438.1999.99050.x.
Obermair, A., Geramou, M., Gücer, F., Denison, U., Graf, A. H., Kapshammer, E., Medl, M., Rosen, A., Wierrani, F., Neunteufel, W., Frech, I., Speiser, P., Kainz, C., & Breitenecker, G. (1999). Endometrial cancer: accuracy of the finding of a well differentiated tumor at dilatation and curettage compared to the findings at subsequent hysterectomy. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 9(5), 383-386. https://doi.org/10.1046/j.1525-1438.1999.99050.x
Obermair, A., et al. "Endometrial cancer: accuracy of the finding of a well differentiated tumor at dilatation and curettage compared to the findings at subsequent hysterectomy." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society vol. 9,5 (1999): 383-386. doi: https://doi.org/10.1046/j.1525-1438.1999.99050.x
Obermair A, Geramou M, Gücer F, Denison U, Graf AH, Kapshammer E, Medl M, Rosen A, Wierrani F, Neunteufel W, Frech I, Speiser P, Kainz C, Breitenecker G. Endometrial cancer: accuracy of the finding of a well differentiated tumor at dilatation and curettage compared to the findings at subsequent hysterectomy. Int J Gynecol Cancer. 1999 Sep;9(5):383-386. doi: 10.1046/j.1525-1438.1999.99050.x. PMID: 11240798.
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Progress and controversies in developing cancer vaccines.

Journal of translational medicine

Slingluff CL, Speiser DE.
PMID: 15862126
J Transl Med. 2005 Apr 29;3(1):18. doi: 10.1186/1479-5876-3-18.

Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2) and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, and there has been substantial progress in identifying shared antigens recognized...

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Slingluff CL, Speiser DE. Progress and controversies in developing cancer vaccines. J Transl Med. 2005;3(1):18doi: 10.1186/1479-5876-3-18.
Slingluff, C. L., & Speiser, D. E. (2005). Progress and controversies in developing cancer vaccines. Journal of translational medicine, 3(1), 18. https://doi.org/10.1186/1479-5876-3-18
Slingluff, Craig L, and Speiser, Daniel E. "Progress and controversies in developing cancer vaccines." Journal of translational medicine vol. 3,1 (2005): 18. doi: https://doi.org/10.1186/1479-5876-3-18
Slingluff CL, Speiser DE. Progress and controversies in developing cancer vaccines. J Transl Med. 2005 Apr 29;3(1):18. doi: 10.1186/1479-5876-3-18. PMID: 15862126; PMCID: PMC1142519.
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Nickel and iron complexes with oxazoline- or pyridine-phosphonite ligands; synthesis, structure and application for the catalytic oligomerisation of ethylene.

Dalton transactions (Cambridge, England : 2003)

Speiser F, Braunstein P, Saussine L.
PMID: 15252602
Dalton Trans. 2004 May 21;(10):1539-45. doi: 10.1039/b401792g. Epub 2004 Apr 20.

The bis(oxazolinyl)phenylphosphonite ligand (bis(4,4-dimethyl-2-(1-hydroxy-1-methylethyl)-4,5-dihydrooxazole)phenylphosphonite, NOPONMe2)) and the new pyridine-phosphonite ligand (2-ethyl(1'-methyl-1-hydroxy)pyridine-6H-dibenz[c,e][1,2]oxaphosphorin) have been used for the preparation of the mononuclear complexes [NiCl2(NOPONMe2)] 18 and [NiCl2(6)2] 19, respectively, which catalyze the oligomerisation of ethylene with activities up to 57300 mol...

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Speiser F, Braunstein P, Saussine L. Nickel and iron complexes with oxazoline- or pyridine-phosphonite ligands; synthesis, structure and application for the catalytic oligomerisation of ethylene. Dalton Trans. 2004;(10):1539-45doi: 10.1039/b401792g.
Speiser, F., Braunstein, P., & Saussine, L. (2004). Nickel and iron complexes with oxazoline- or pyridine-phosphonite ligands; synthesis, structure and application for the catalytic oligomerisation of ethylene. Dalton transactions (Cambridge, England : 2003), (10), 1539-45. https://doi.org/10.1039/b401792g
Speiser, Fredy, et al. "Nickel and iron complexes with oxazoline- or pyridine-phosphonite ligands; synthesis, structure and application for the catalytic oligomerisation of ethylene." Dalton transactions (Cambridge, England : 2003) vol. ,10 (2004): 1539-45. doi: https://doi.org/10.1039/b401792g
Speiser F, Braunstein P, Saussine L. Nickel and iron complexes with oxazoline- or pyridine-phosphonite ligands; synthesis, structure and application for the catalytic oligomerisation of ethylene. Dalton Trans. 2004 May 21;(10):1539-45. doi: 10.1039/b401792g. Epub 2004 Apr 20. PMID: 15252602.
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Demographics and anthropometrics impact benefits of health intervention: data from the Reduce Obesity and Diabetes Project.

Obesity science & practice

Ostrowski L, Speiser PW, Accacha S, Altshuler L, Fennoy I, Lowell B, Rapaport R, Rosenfeld W, Shelov SP, Ten S, Rosenbaum M.
PMID: 30847225
Obes Sci Pract. 2019 Jan 16;5(1):46-58. doi: 10.1002/osp4.310. eCollection 2019 Feb.

OBJECTIVE: To determine the efficacy of a 4-month school-based health, nutrition and exercise intervention on body fatness and examine possible effects of demographic and anthropometric covariates.METHODS: Height, weight, waist circumference and body composition were measured in a diverse population...

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Ostrowski L, Speiser PW, Accacha S, et al. Demographics and anthropometrics impact benefits of health intervention: data from the Reduce Obesity and Diabetes Project. Obes Sci Pract. 2019;5(1):46-58doi: 10.1002/osp4.310.
Ostrowski, L., Speiser, P. W., Accacha, S., Altshuler, L., Fennoy, I., Lowell, B., Rapaport, R., Rosenfeld, W., Shelov, S. P., Ten, S., Rosenbaum, M. (2019). Demographics and anthropometrics impact benefits of health intervention: data from the Reduce Obesity and Diabetes Project. Obesity science & practice, 5(1), 46-58. https://doi.org/10.1002/osp4.310
Ostrowski, L, et al. "Demographics and anthropometrics impact benefits of health intervention: data from the Reduce Obesity and Diabetes Project." Obesity science & practice vol. 5,1 (2019): 46-58. doi: https://doi.org/10.1002/osp4.310
Ostrowski L, Speiser PW, Accacha S, Altshuler L, Fennoy I, Lowell B, Rapaport R, Rosenfeld W, Shelov SP, Ten S, Rosenbaum M. Demographics and anthropometrics impact benefits of health intervention: data from the Reduce Obesity and Diabetes Project. Obes Sci Pract. 2019 Jan 16;5(1):46-58. doi: 10.1002/osp4.310. eCollection 2019 Feb. PMID: 30847225; PMCID: PMC6381301.
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Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes.

Frontiers in molecular biosciences

Schipper-Krom S, Sanz AS, van Bodegraven EJ, Speijer D, Florea BI, Ovaa H, Reits EA.
PMID: 31482094
Front Mol Biosci. 2019 Aug 20;6:56. doi: 10.3389/fmolb.2019.00056. eCollection 2019.

The proteasome is a multi-catalytic molecular machine that plays a key role in the degradation of many cytoplasmic and nuclear proteins. The proteasome is essential and proteasome malfunction is associated with various disease pathologies. Proteasome activity depends on its...

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Schipper-Krom S, Sanz AS, van Bodegraven EJ, et al. Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes. Front Mol Biosci. 2019;6:56doi: 10.3389/fmolb.2019.00056.
Schipper-Krom, S., Sanz, A. S., van Bodegraven, E. J., Speijer, D., Florea, B. I., Ovaa, H., & Reits, E. A. (2019). Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes. Frontiers in molecular biosciences, 656. https://doi.org/10.3389/fmolb.2019.00056
Schipper-Krom, Sabine, et al. "Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes." Frontiers in molecular biosciences vol. 6 (2019): 56. doi: https://doi.org/10.3389/fmolb.2019.00056
Schipper-Krom S, Sanz AS, van Bodegraven EJ, Speijer D, Florea BI, Ovaa H, Reits EA. Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes. Front Mol Biosci. 2019 Aug 20;6:56. doi: 10.3389/fmolb.2019.00056. eCollection 2019. PMID: 31482094; PMCID: PMC6710370.
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Showing 1 to 12 of 190 entries