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Liu Y, Gu X, Lin Q, et al. Prognostic significance of osteopontin in patients with non-small cell lung cancer: results from a meta-analysis. Int J Clin Exp Med. 2015;8(8):12765-73
Liu, Y., Gu, X., Lin, Q., Tian, T., Shao, L., Yuan, C., Zhang, B., & Fan, K. (2015). Prognostic significance of osteopontin in patients with non-small cell lung cancer: results from a meta-analysis. International journal of clinical and experimental medicine, 8(8), 12765-73.
Liu, Yang, et al. "Prognostic significance of osteopontin in patients with non-small cell lung cancer: results from a meta-analysis." International journal of clinical and experimental medicine vol. 8,8 (2015): 12765-73.
Liu Y, Gu X, Lin Q, Tian T, Shao L, Yuan C, Zhang B, Fan K. Prognostic significance of osteopontin in patients with non-small cell lung cancer: results from a meta-analysis. Int J Clin Exp Med. 2015 Aug 15;8(8):12765-73. eCollection 2015. PMID: 26550190; PMCID: PMC4612875.
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Int J Clin Exp Med. 2015 Aug 15;8(8):12765-73. eCollection 2015.

Prognostic significance of osteopontin in patients with non-small cell lung cancer: results from a meta-analysis.

International journal of clinical and experimental medicine

Yang Liu, Xiaobin Gu, Qunying Lin, Tian Tian, Lijuan Shao, Chao Yuan, Bo Zhang, Kexing Fan

Affiliations

  1. Department of Cancer Center, Chinese PLA General Hospital and Chinese PLA Medical School Beijing, China.
  2. Department of Respiratory Medicine, Hospital of Putian University Putian, Fujian, China.
  3. School of Medicine, Nankai University Tianjin, China.
  4. Department of Cancer Center, Chinese PLA General Hospital and Chinese PLA Medical School Beijing, China ; Department of International Joint Cancer Institute, The Second Military Medical University Shanghai, China.

PMID: 26550190 PMCID: PMC4612875

Abstract

BACKGROUNDS: Non-small cell lung cancer (NSCLC) is one of the most common malignancies with a high mortality level. Recently, a variety of studies explored the role of osteopontin (OPN) expression in the prognosis of NSCLC, but the results were controversial.

METHODS: We performed a meta-analysis of eligible studies to evaluate the prognostic significance of OPN expression in NSCLC patients. In order to assess the association between OPN and OS and DFS/PFS, hazard ratio (HR) with 95% confidence interval (CI) was calculated.

RESULTS: A total of ten studies comprising 1420 patients were included in the meta-analysis. The summary results indicated that high OPN expression was a poor predictor for OS (HR = 2.19, 95% CI: 1.6-2.98), and DFS/PFS (HR = 2, 95% CI: 1.66-2.41). Subgroup analysis revealed that high OPN expression was a negative prognostic marker for OS and DFS/PFS regardless of ethnicity background, treatment and OPN detection method.

CONCLUSION: Our results showed that increased OPN expression significantly correlated with poor OS and DPS/PFS in NSCLC patients.

Keywords: Non-small cell lung cancer; biomarker; osteopontin; prognosis

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