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Zhu B, Xiao C, Zhu B, et al. Little association between the interleukin 10-3575T/A polymorphism and cancer risk: pooled analysis of 15608 cancer cases and 17539 controls. Int J Clin Exp Med. 2015;8(8):14335-44
Zhu, B., Xiao, C., Zhu, B., Zheng, Z., & Liang, J. (2015). Little association between the interleukin 10-3575T/A polymorphism and cancer risk: pooled analysis of 15608 cancer cases and 17539 controls. International journal of clinical and experimental medicine, 8(8), 14335-44.
Zhu, Biyuan, et al. "Little association between the interleukin 10-3575T/A polymorphism and cancer risk: pooled analysis of 15608 cancer cases and 17539 controls." International journal of clinical and experimental medicine vol. 8,8 (2015): 14335-44.
Zhu B, Xiao C, Zhu B, Zheng Z, Liang J. Little association between the interleukin 10-3575T/A polymorphism and cancer risk: pooled analysis of 15608 cancer cases and 17539 controls. Int J Clin Exp Med. 2015 Aug 15;8(8):14335-44. eCollection 2015. PMID: 26550419; PMCID: PMC4613104.
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Int J Clin Exp Med. 2015 Aug 15;8(8):14335-44. eCollection 2015.

Little association between the interleukin 10-3575T/A polymorphism and cancer risk: pooled analysis of 15608 cancer cases and 17539 controls.

International journal of clinical and experimental medicine

Biyuan Zhu, Chaolie Xiao, Biqing Zhu, Zhiwen Zheng, Jingjing Liang

Affiliations

  1. Department of Respiratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China ; Department of Intensive Care Unit, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.
  2. Department of Intensive Care Unit, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.
  3. Department of Laboratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.
  4. Department of Respiratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.

PMID: 26550419 PMCID: PMC4613104

Abstract

The aim of the present work was to evaluate the association between the interleukin 10 (IL-10) -3575T/A (rs1800890) polymorphism and cancer risk. We performed a met-analysis based on 15 studies, including 15608 cancer cases and 17539 controls. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association, and performed sensitivity analyses. In the stratified analyses by all included studies, no association between IL-10-3575T/A (rs1800890) polymorphism and cancer risk (OR=0.966, 95% CI=0.889-1.05, P=0.417 for A vs. T; OR=1.035, 95% CI=0.975-1.1, P=0.257 for AA vs. AT+TT; OR=1.008, 95% CI=0.964-1.054, P=0.723 for AA+AT vs. TT) was observed. In the stratified analyses by cancer type of lymphoma and non-lymphoma, no association between them was also detected (Lymphoma: OR=1.021, 95% CI=0.962-1.083, P=0.496 for A vs. T; OR=1.029, 95% CI=0.967-1.095, P=0.363 for AA vs. AT+TT; OR=1.017, 95% CI=0.952-1.086, P=0.626 for AA+AT vs. TT; Non-lymphoma: OR=0.966 95% CI=0.889-1.51, P=0.245 for A vs. T; OR=1.035, 95% CI=0.975-1.1, P=0.287 for AA vs. AT+TT; OR=1.017, 95% CI=0.948-1.091, P=0.967 for AA+AT vs. TT). The results were the same by sensitivity analyses. No publication bias was existed in the analysis. The interleukin 10-3575T/A polymorphism may have no association with cancer risk.

Keywords: Interleukin 10; cancer; meta-analysis; polymorphism

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