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Durrant DM, Williams JL, Daniels BP, et al. Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease. Adv Med. 2014;2014:806741doi: 10.1155/2014/806741.
Durrant, D. M., Williams, J. L., Daniels, B. P., & Klein, R. S. (2014). Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease. Advances in medicine, 2014806741. https://doi.org/10.1155/2014/806741
Durrant, Douglas M, et al. "Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease." Advances in medicine vol. 2014 (2014): 806741. doi: https://doi.org/10.1155/2014/806741
Durrant DM, Williams JL, Daniels BP, Klein RS. Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease. Adv Med. 2014;2014:806741. doi: 10.1155/2014/806741. Epub 2014 Sep 30. PMID: 26556427; PMCID: PMC4590974.
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Adv Med. 2014;2014:806741. doi: 10.1155/2014/806741. Epub 2014 Sep 30.

Chemokines Referee Inflammation within the Central Nervous System during Infection and Disease.

Advances in medicine

Douglas M Durrant, Jessica L Williams, Brian P Daniels, Robyn S Klein

Affiliations

  1. Department of Internal Medicine, Washington University School of Medicine, Campus Box 8051, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
  2. Department of Internal Medicine, Washington University School of Medicine, Campus Box 8051, 660 S. Euclid Avenue, St. Louis, MO 63110, USA ; Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8051, 660 S. Euclid Avenue, St. Louis, MO 63110, USA ; Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8051, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

PMID: 26556427 PMCID: PMC4590974 DOI: 10.1155/2014/806741

Abstract

The discovery that chemokines and their receptors are expressed by a variety of cell types within the normal adult central nervous system (CNS) has led to an expansion of their repertoire as molecular interfaces between the immune and nervous systems. Thus, CNS chemokines are now divided into those molecules that regulate inflammatory cell migration into the CNS and those that initiate CNS repair from inflammation-mediated tissue damage. Work in our laboratory throughout the past decade has sought to elucidate how chemokines coordinate leukocyte entry and interactions at CNS endothelial barriers, under both homeostatic and inflammatory conditions, and how they promote repair within the CNS parenchyma. These studies have identified several chemokines, including CXCL12 and CXCL10, as critical regulators of leukocyte migration from perivascular locations. CXCL12 additionally plays an essential role in promoting remyelination of injured white matter. In both scenarios we have shown that chemokines serve as molecular links between inflammatory mediators and other effector molecules involved in neuroprotective processes.

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