Display options
Cite
Rahaghi FN, Come CE, Ross J, et al. Morphologic Response of the Pulmonary Vasculature to Endoscopic Lung Volume Reduction. Chronic Obstr Pulm Dis. 2015;2(3):214-222doi: 10.15326/jcopdf.2.3.2014.0164.
Rahaghi, F. N., Come, C. E., Ross, J., Harmouche, R., Diaz, A. A., Estepar, R. S., & Washko, G. (2015). Morphologic Response of the Pulmonary Vasculature to Endoscopic Lung Volume Reduction. Chronic obstructive pulmonary diseases (Miami, Fla.), 2(3), 214-222. https://doi.org/10.15326/jcopdf.2.3.2014.0164
Rahaghi, Farbod N, et al. "Morphologic Response of the Pulmonary Vasculature to Endoscopic Lung Volume Reduction." Chronic obstructive pulmonary diseases (Miami, Fla.) vol. 2,3 (2015): 214-222. doi: https://doi.org/10.15326/jcopdf.2.3.2014.0164
Rahaghi FN, Come CE, Ross J, Harmouche R, Diaz AA, Estepar RS, Washko G. Morphologic Response of the Pulmonary Vasculature to Endoscopic Lung Volume Reduction. Chronic Obstr Pulm Dis. 2015;2(3):214-222. doi: 10.15326/jcopdf.2.3.2014.0164. PMID: 26587564; PMCID: PMC4648543.
Copy Download .nbib Format: NLM
Share it on

Chronic Obstr Pulm Dis. 2015;2(3):214-222. doi: 10.15326/jcopdf.2.3.2014.0164.

Morphologic Response of the Pulmonary Vasculature to Endoscopic Lung Volume Reduction.

Chronic obstructive pulmonary diseases (Miami, Fla.)

Farbod N Rahaghi, Carolyn E Come, James Ross, Rola Harmouche, Alejandro A Diaz, Raul San Jose Estepar, George Washko

Affiliations

  1. Brigham and Women's Hospital, Pulmonary and Critical Care Division of Department of Medicine, 75 Francis Street, PBB - CA 3, Boston, MA 02115.
  2. Deparment of Radiology, Harvard School of Medicine, Surgical Planning Laboratory, 1249 Boylston Street, 2nd Floor, Room 216.
  3. Deparment of Radiology, Harvard School of Medicine, Surgical Planning Laboratory, 1249 Boylston Street, 2nd Floor, Room 216, Boston MA 02215.

PMID: 26587564 PMCID: PMC4648543 DOI: 10.15326/jcopdf.2.3.2014.0164

Abstract

INTRODUCTION: Endoscopic Lung Volume Reduction has been used to reduce lung hyperinflation in selected patients with severe emphysema. Little is known about the effect of this procedure on the intraparenchymal pulmonary vasculature. In this study we used CT based vascular reconstruction to quantify the effect of the procedure on the pulmonary vasculature.

METHODS: Intraparenchymal vasculature was reconstructed and quantified in 12 patients with CT scans at baseline and 12 weeks following bilateral introduction of sealants in the upper lobes. The volume of each lung and each lobe was measured, and the vascular volume profile was calculated for both lower lobes. The detected vasculature was further labeled manually as arterial or venous in the right lower lobe.

RESULTS: There was an increase in the volume of the lower lobes (3.14L to 3.25L, p=0.0005). There was an increase in BV5, defined as the volume of blood vessels with cross sectional area of less than 5mm

CONCLUSION: In the subjects studied, there was an increase, from baseline, in BV5 in the lower lobes that correlated with the change in the volume of the lower lobes. The change appeared to be symmetric for both arteries and veins. The study illustrates the use of intraparenchymal pulmonary vascular reconstruction to study morphologic changes in response to interventions.

References

  1. Am J Respir Crit Care Med. 1997 Jun;155(6):1984-90 - PubMed
  2. AJR Am J Roentgenol. 2014 Apr;202(4):719-24 - PubMed
  3. Am J Respir Crit Care Med. 2013 Jul 15;188(2):231-9 - PubMed
  4. Acad Radiol. 2010 Jan;17 (1):93-9 - PubMed
  5. Respir Med. 2012 Jan;106(1):109-19 - PubMed
  6. IEEE Trans Vis Comput Graph. 2009 Nov-Dec;15(6):1415-24 - PubMed
  7. Acad Radiol. 2011 Jan;18(1):40-6 - PubMed
  8. Am J Respir Crit Care Med. 1998 Oct;158(4):1020-5 - PubMed
  9. Am J Respir Crit Care Med. 2002 Feb 15;165(4):489-94 - PubMed
  10. Chest. 2003 Nov;124(5):1863-70 - PubMed
  11. Proc IEEE Int Symp Biomed Imaging. 2012;:1479-1482 - PubMed
  12. Am J Respir Crit Care Med. 2007 Aug 1;176(3):253-60 - PubMed
  13. N Engl J Med. 2003 May 22;348(21):2059-73 - PubMed
  14. N Engl J Med. 2010 Sep 23;363(13):1233-44 - PubMed
  15. Med Image Comput Comput Assist Interv. 2009;12 (Pt 2):690-8 - PubMed
  16. Chest. 2012 Nov;142(5):1111-7 - PubMed
  17. Chest. 2009 May;135(5):1268-79 - PubMed
  18. Am J Respir Crit Care Med. 2010 Feb 1;181(3):218-25 - PubMed

Publication Types

Grant support