Display options
Cite
Yang N, Liu H, Jiang Y, et al. Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy. Neural Regen Res. 2015;10(9):1457-62doi: 10.4103/1673-5374.165516.
Yang, N., Liu, H., Jiang, Y., Zheng, J., Li, D. M., Ji, C., Liu, Y. Y., & Zuo, P. P. (2015). Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy. Neural regeneration research, 10(9), 1457-62. https://doi.org/10.4103/1673-5374.165516
Yang, Nan, et al. "Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy." Neural regeneration research vol. 10,9 (2015): 1457-62. doi: https://doi.org/10.4103/1673-5374.165516
Yang N, Liu H, Jiang Y, Zheng J, Li DM, Ji C, Liu YY, Zuo PP. Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy. Neural Regen Res. 2015 Sep;10(9):1457-62. doi: 10.4103/1673-5374.165516. PMID: 26604907; PMCID: PMC4625512.
Copy Download .nbib Format: NLM
Share it on

Neural Regen Res. 2015 Sep;10(9):1457-62. doi: 10.4103/1673-5374.165516.

Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy.

Neural regeneration research

Nan Yang, He Liu, Yao Jiang, Ji Zheng, Dong-Mei Li, Chao Ji, Yan-Yong Liu, Ping-Ping Zuo

Affiliations

  1. Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China.

PMID: 26604907 PMCID: PMC4625512 DOI: 10.4103/1673-5374.165516

Abstract

Lactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy induced by carbon tetrachloride. Immunohistochemistry showed that lactulose treatment promoted neurogenesis and increased the number of neurons and astrocytes in the hippocampus. Moreover, lactulose-treated rats showed shorter escape latencies than model rats in the Morris water maze, indicating that lactulose improved the cognitive impairments caused by hepatic encephalopathy. The present findings suggest that lactulose effectively improves cognitive function by enhancing neuroplasticity in a rat model of early hepatic encephalopathy.

Keywords: Morris water maze; NSFC grants; brain injury; cognition; glial fibrillary acidic protein; hepatic encephalopathy; lactulose; nerve regeneration; neural regeneration; neurogenesis; neuronal nuclei; neuroplasticity; rats

References

  1. Med Gas Res. 2012 Feb 06;2:3 - PubMed
  2. J Histochem Cytochem. 2005 Jul;53(7):821-32 - PubMed
  3. Metab Brain Dis. 2013 Jun;28(2):313-20 - PubMed
  4. Arab J Gastroenterol. 2013 Sep;14(3):116-22 - PubMed
  5. Cell. 2008 Feb 22;132(4):645-60 - PubMed
  6. Neurochem Int. 2011 Jul;58(8):904-13 - PubMed
  7. J Alzheimers Dis. 2009;16(2):331-9 - PubMed
  8. Hepatology. 2002 Mar;35(3):716-21 - PubMed
  9. World J Gastroenterol. 2010 Mar 28;16(12):1458-64 - PubMed
  10. Hepatology. 2010 Jul;52(1):256-65 - PubMed
  11. Neurochem Int. 2002 Aug-Sep;41(2-3):155-60 - PubMed
  12. Prog Neurobiol. 2002 Jul;67(4):259-79 - PubMed
  13. J Hepatol. 2006 Jan;44(1):104-10 - PubMed
  14. Nat Rev Neurosci. 2013 Dec;14(12):851-8 - PubMed
  15. Brain Behav Evol. 2011;78(1):94-107 - PubMed
  16. Eur J Gastroenterol Hepatol. 2011 Nov;23(12):1250-7 - PubMed
  17. J Alzheimers Dis. 2012;31(1):101-11 - PubMed
  18. J Neuropathol Exp Neurol. 1990 Jul;49(4):399-405 - PubMed
  19. J Hepatol. 1991 Nov;13(3):372-4 - PubMed
  20. Metab Brain Dis. 2010 Mar;25(1):17-21 - PubMed
  21. Hepatology. 2007 Mar;45(3):549-59 - PubMed
  22. Am J Gastroenterol. 2001 Jul;96(7):1968-76 - PubMed
  23. Am J Gastroenterol. 2013 Sep;108(9):1458-63 - PubMed
  24. J Cereb Blood Flow Metab. 1991 Mar;11(2):337-41 - PubMed
  25. Brain Res Rev. 2007 Jan;53(1):198-214 - PubMed
  26. Ann Neurol. 2008 Oct;64(4):434-45 - PubMed
  27. J Neurochem. 1994 Dec;63(6):2021-7 - PubMed
  28. N Engl J Med. 1997 Aug 14;337(7):473-9 - PubMed
  29. J Hepatol. 2000 Jun;32(6):1035-8 - PubMed
  30. J Clin Invest. 1986 Jul;78(1):86-95 - PubMed
  31. J Anat. 2007 Aug;211(2):164-76 - PubMed
  32. Liver Transpl. 2009 May;15(5):484-95 - PubMed
  33. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6644-9 - PubMed
  34. Behav Brain Res. 2008 Mar 17;188(1):32-40 - PubMed
  35. Dialogues Clin Neurosci. 2006;8(4):367-81 - PubMed

Publication Types