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Kim JW, Oh MM, Yeo JK, et al. Efficacy of Dose Escalation of Tamsulosin for the Treatment of Lower Urinary Tract Symptoms. Low Urin Tract Symptoms. 2012;4(2):96-102doi: 10.1111/j.1757-5672.2012.00141.x.
Kim, J. W., Oh, M. M., Yeo, J. K., Bae, J. H., Joo, K. J., Choi, J. B., Park, H. S., Kim, H. J., Moon, d. u. . G., & Lee, J. G. (2012). Efficacy of Dose Escalation of Tamsulosin for the Treatment of Lower Urinary Tract Symptoms. Lower urinary tract symptoms, 4(2), 96-102. https://doi.org/10.1111/j.1757-5672.2012.00141.x
Kim, Jin Wook, et al. "Efficacy of Dose Escalation of Tamsulosin for the Treatment of Lower Urinary Tract Symptoms." Lower urinary tract symptoms vol. 4,2 (2012): 96-102. doi: https://doi.org/10.1111/j.1757-5672.2012.00141.x
Kim JW, Oh MM, Yeo JK, Bae JH, Joo KJ, Choi JB, Park HS, Kim HJ, Moon du G, Lee JG. Efficacy of Dose Escalation of Tamsulosin for the Treatment of Lower Urinary Tract Symptoms. Low Urin Tract Symptoms. 2012 May;4(2):96-102. doi: 10.1111/j.1757-5672.2012.00141.x. Epub 2012 Feb 17. PMID: 26676533.
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Low Urin Tract Symptoms. 2012 May;4(2):96-102. doi: 10.1111/j.1757-5672.2012.00141.x. Epub 2012 Feb 17.

Efficacy of Dose Escalation of Tamsulosin for the Treatment of Lower Urinary Tract Symptoms.

Lower urinary tract symptoms

Jin Wook Kim, Mi Mi Oh, Jeong Kyun Yeo, Jae Hyun Bae, Kwan Joong Joo, Jong Bo Choi, Hong Seok Park, Hyung Jee Kim, Du Geon Moon, Jeong Gu Lee

Affiliations

  1. Department of Urology, Korea University College of Medicine, Guro Hospital, Seoul, KoreaDepartment of Urology, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Urology, Korea University College of Medicine, Ansan Hospital, Ansan, KoreaDepartment of Urology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, KoreaDepartment of Urology, Ajou University College of Medicine, Suwon, KoreaDepartment of Urology, Dankook University College of Medicine, Seoul, KoreaDepartment of Urology, Korea University College of Medicine, Anam Hospital, Seoul, Korea.

PMID: 26676533 DOI: 10.1111/j.1757-5672.2012.00141.x

Abstract

OBJECTIVES: The aim of this study was to compare the efficacy of low (0.2 mg) and intermediate (0.4 mg) dose tamsulosin in treating lower urinary tract symptoms (LUTS).

METHODS: Patients were treated with low-dose tamsulosin for an initial run-in period of 12 weeks, then divided into two groups based on their clinical improvement. Patients were measured for objective parameters of peak flow rate and postvoid residual urine volume, as well as subjective symptom scores and perceived patient benefit of treatment. The items were then integrated as the LUTS Outcome Score to determine dose increase or maintenance. Overall outcome was determined at 36 weeks.

RESULTS: One hundred and seventy-four patients were enrolled and started on 0.2 mg tamsulosin treatment. One hundred and fifty-five patients completed the 36-week study. Sixty patients required dose increase to 0.4 mg at the 12th week. Baseline characteristics showed that a patient who would benefit from 0.4 mg dosage had higher age, daytime frequency, and lower peak urine flow rate. Patients receiving both 0.2 and 0.04 mg both showed improved clinical outcome measures. Higher improvement was found in voiding component symptom scores and urine flow rate improvement in patients receiving an increased dose.

CONCLUSION: Both low- and intermediate-dose tamsulosin are effective treatment regimens. Increasing from low to intermediate dose should follow assessment of both objective and subjective improvements.

© 2012 Blackwell Publishing Asia Pty Ltd.

Keywords: adrenergic alpha-antagonist; benign prostatic hyperplasia; drug therapy; tamsulosin

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