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Eide PK, Ringstad G. MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain. Acta Radiol Open. 2015;4(11):2058460115609635doi: 10.1177/2058460115609635.
Eide, P. K., & Ringstad, G. (2015). MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain. Acta radiologica open, 4(11), 2058460115609635. https://doi.org/10.1177/2058460115609635
Eide, Per Kristian, and Ringstad, Geir. "MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain." Acta radiologica open vol. 4,11 (2015): 2058460115609635. doi: https://doi.org/10.1177/2058460115609635
Eide PK, Ringstad G. MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain. Acta Radiol Open. 2015 Nov 17;4(11):2058460115609635. doi: 10.1177/2058460115609635. eCollection 2015 Nov. PMID: 26634147; PMCID: PMC4652208.
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Acta Radiol Open. 2015 Nov 17;4(11):2058460115609635. doi: 10.1177/2058460115609635. eCollection 2015 Nov.

MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain.

Acta radiologica open

Per Kristian Eide, Geir Ringstad

Affiliations

  1. Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway ; Faculty of Medicine, University of Oslo, Oslo, Norway.
  2. Department of Radiology and Nuclear Medicine, Oslo University Hospital - Rikshospitalet, Oslo, Norway.

PMID: 26634147 PMCID: PMC4652208 DOI: 10.1177/2058460115609635

Abstract

Recently, the "glymphatic system" of the brain has been discovered in rodents, which is a paravascular, transparenchymal route for clearance of excess brain metabolites and distribution of compounds in the cerebrospinal fluid. It has already been demonstrated that intrathecally administered gadolinium (Gd) contrast medium distributes along this route in rats, but so far not in humans. A 27-year-old woman underwent magnetic resonance imaging (MRI) with intrathecal administration of gadobutrol, which distributed throughout her entire brain after 1 and 4.5 h. MRI with intrathecal Gd may become a tool to study glymphatic function in the human brain.

Keywords: Magnetic resonance imaging (MRI); brain; contrast medium; glymphatic circulation; intrathecal; paravascular transport

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