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Sanders GL, Davies DM, Gales GM, et al. A comparative study of methyldopa and labetalol in the treatment of hypertension. Br J Clin Pharmacol. 1979;8:149S-51Sdoi: 10.1111/j.1365-2125.1979.tb04771.x.
Sanders, G. L., Davies, D. M., Gales, G. M., Rao, J. G., Rawlins, M. D., & Routledge, P. A. (1979). A comparative study of methyldopa and labetalol in the treatment of hypertension. British journal of clinical pharmacology, 8149S-51S. https://doi.org/10.1111/j.1365-2125.1979.tb04771.x
Sanders, G L, et al. "A comparative study of methyldopa and labetalol in the treatment of hypertension." British journal of clinical pharmacology vol. 8 (1979): 149S-51S. doi: https://doi.org/10.1111/j.1365-2125.1979.tb04771.x
Sanders GL, Davies DM, Gales GM, Rao JG, Rawlins MD, Routledge PA. A comparative study of methyldopa and labetalol in the treatment of hypertension. Br J Clin Pharmacol. 1979 Apr;8:149S-51S. doi: 10.1111/j.1365-2125.1979.tb04771.x. PMID: 26635157.
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Br J Clin Pharmacol. 1979 Apr;8:149S-51S. doi: 10.1111/j.1365-2125.1979.tb04771.x.

A comparative study of methyldopa and labetalol in the treatment of hypertension.

British journal of clinical pharmacology

G L Sanders, D M Davies, G M Gales, J G Rao, M D Rawlins, P A Routledge

PMID: 26635157 DOI: 10.1111/j.1365-2125.1979.tb04771.x

Abstract

1 Twenty patients with essential hypertension completed a double-blind, dose-tritrated, cross-over comparison of methyldopa and labetalol. 2 Average lying BPs (systolic/diastolic) were reduced by 28/15 mmHg with methyldopa and by 23/15 mmHg with labetalol. 3 Average standing BPs (systolic/diastolic) were reduced by 29/14 mmHg with methyldopa and by 29/15 mmHg with labetalol. 4 Both lying and standing heart rates were reduced with labetalol. 5 It is concluded that the antihypertensive properties of labetalol and methyldopa are similar but that larger patient populations are needed to study the relative incidence of subjective adverse effects.

1979 The British Pharmacological Society.

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