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Showing 1 to 12 of 114 entries
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Spontaneous reporting of adverse drug reactions.

The Quarterly journal of medicine

Rawlins MD.
PMID: 3749447
Q J Med. 1986 Jun;59(230):531-4.

No abstract available.

Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation.

ACS medicinal chemistry letters

Goodwin NC, Cianchetta G, Burgoon HA, Healy J, Mabon R, Strobel ED, Allen J, Wang S, Hamman BD, Rawlins DB.
PMID: 25589930
ACS Med Chem Lett. 2014 Aug 07;6(1):53-7. doi: 10.1021/ml500242y. eCollection 2015 Jan 08.

The first allosteric, type III inhibitor of LIM-kinase 2 (LIMK2) is reported. A series of molecules that feature both an N-phenylsulfonamide and tertiary amide were not only very potent at LIMK2 but also were extremely selective against a panel...

A comparative study of methyldopa and labetalol in the treatment of hypertension.

British journal of clinical pharmacology

Sanders GL, Davies DM, Gales GM, Rao JG, Rawlins MD, Routledge PA.
PMID: 26635157
Br J Clin Pharmacol. 1979 Apr;8:149S-51S. doi: 10.1111/j.1365-2125.1979.tb04771.x.

1 Twenty patients with essential hypertension completed a double-blind, dose-tritrated, cross-over comparison of methyldopa and labetalol. 2 Average lying BPs (systolic/diastolic) were reduced by 28/15 mmHg with methyldopa and by 23/15 mmHg with labetalol. 3 Average standing BPs (systolic/diastolic)...

A multicentre open trial of labetalol in New Zealand.

British journal of clinical pharmacology

Sanders GL, Davies DM, Gales GM, Rao JG, Rawlins MD, Routledge PA.
PMID: 26635163
Br J Clin Pharmacol. 1979 Apr;8:179S-82S. doi: 10.1111/j.1365-2125.1979.tb04777.x.

1 In a multicentre open trial, labetalol was given to 128 patients in ten centres. Forty-three patients had not previously received antihypertensive therapy; the remainder (85 patients) had been on antihypertensive therapy with either unsatisfactory BP control or troublesome...

Measurable and Influential Parameters That Influence Corrosion Performance Differences between Multiwall Carbon Nanotube Coating Material Combinations and Model Parent Material Combinations Derived from Epoxy-Amine Matrix Materials.

ACS applied materials & interfaces

Curtzwiler GW, Williams EB, Maples AL, Wand SW, Rawlins JW.
PMID: 28112508
ACS Appl Mater Interfaces. 2017 Feb 22;9(7):6356-6368. doi: 10.1021/acsami.6b13469. Epub 2017 Feb 10.

Protective coatings are often erroneously thought of as perfect environmental barriers for metal substrates; however, a host of corrosion inducing environmental contaminants permeate through defect-free coatings. Carbon nanotubes are high aspect ratio nanofillers with unique mechanical, electrical, and polymer...

Electrical burn injuries secondary to copper theft.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

Dunne JA, Wilks DJ, Mather DP, Rawlins JM.
PMID: 26038016
Eur J Trauma Emerg Surg. 2015 Dec;41(6):689-90. doi: 10.1007/s00068-015-0495-y. Epub 2015 Jan 29.

No abstract available.

Estimation of ozone with total ozone portable spectroradiometer instruments. II. Practical operation and comparisons.

Applied optics

Labow GJ, Flynn LE, Rawlins MA, Beach RA, Simmons CA, Schubert CM.
PMID: 21127624
Appl Opt. 1996 Oct 20;35(30):6084-9. doi: 10.1364/AO.35.006084.

We used a microcomputer-controlled total ozone portable spectroradiometer instrument #21 (MTOPS21) to measure solar radiation at 298, 304 and 310 nm in Greenbelt, Md., during 1995. One day's ozone measurements from a Brewer instrument (B105) were used to calibrate...

A large and accurate collection of peptidase cleavages in the MEROPS database.

Database : the journal of biological databases and curation

Rawlings ND.
PMID: 20157488
Database (Oxford). 2009;2009:bap015. doi: 10.1093/database/bap015. Epub 2009 Nov 02.

Peptidases are enzymes that hydrolyse peptide bonds in proteins and peptides. Peptidases are important in pathological conditions such as Alzheimer's disease, tumour and parasite invasion, and for processing viral polyproteins. The MEROPS database is an Internet resource containing information...

REPORT OF THE COMMITTEE ON THE STUDY AND PREVENTION OF COMMUNICABLE DISEASES.

American journal of public health (New York, N.Y. : 1912)

Curtis FG, Arteaga JF, Chapin CV, Rawlings SD.
PMID: 18009010
Am J Public Health (N Y). 1914 Mar;4(3):253-7. doi: 10.2105/ajph.4.3.253.

No abstract available.

Lumbar spine intervertebral disc gene delivery: a pilot study in lewis rats.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery

Damle SR, Rawlins BA, Boachie-Adjei O, Crystal RG, Hidaka C, Cunningham ME.
PMID: 24426843
HSS J. 2013 Feb;9(1):36-41. doi: 10.1007/s11420-012-9319-3. Epub 2013 Jan 08.

BACKGROUND: Basic research toward understanding and treating disc pathology in the spine has utilized numerous animal models, with delivery of small molecules, purified factors, and genes of interest. To date, gene delivery to the rat lumbar spine has only...

The Chemotherapy of Gonorrhœa Failures. Their Cause and Prevention.

The British journal of venereal diseases

Rawlins M.
PMID: 21773303
Br J Vener Dis. 1940 Jul;16(3):232-6. doi: 10.1136/sti.16.3-4.232.

No abstract available.

Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms.

Molecular psychiatry

Skelly DT, Griffin ÉW, Murray CL, Harney S, O'Boyle C, Hennessy E, Dansereau MA, Nazmi A, Tortorelli L, Rawlins JN, Bannerman DM, Cunningham C.
PMID: 30890763
Mol Psychiatry. 2019 Oct;24(10):1566. doi: 10.1038/s41380-019-0403-7.

Following publication of this article, the authors noticed an error in the abstract, where they incorrectly stated that: "Direct application of IL-1β to ex vivo hippocampal slices induced non-synaptic depolarisation and irreversible loss of membrane potential in CA1 neurons...

Showing 1 to 12 of 114 entries