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Int J Clin Exp Med. 2015 Oct 15;8(10):18528-32. eCollection 2015.

Tumor abnormal protein (TAP) examination contributes to primary diagnosis of bladder cancer.

International journal of clinical and experimental medicine

Liqing Zhang, Xiuxia Guo, Yongzheng Min, Jianjiang Xu

Affiliations

  1. Department of Urology Surgery, General Hospital of Jinan Military Command Jinan, China.
  2. Department of Gynecology, General Hospital of Jinan Military Command Jinan, China.
  3. Department of Pharmacy, General Hospital of Jinan Military Command Jinan, China.

PMID: 26770464 PMCID: PMC4694364

Abstract

OBJECTIVE: This study aims to investigate the application value of tumor abnormal protein (TAP) examination in the diagnosis of urothelial carcinoma of the bladder.

METHOD: Abnormal sugar chain glycoproteins in the peripheral blood of 87 patients with urothelial carcinoma of the bladder were detected, and compared with non-tumor patients accompanied by hematuria.

RESULT: TAP examination showed that the positive rate of the abnormal sugar chain glycoprotein in the peripheral blood of the 87 patients with urothelial carcinoma of the bladder was 78.16%, whereas that of the non-tumor patients was 10.81%. The former is significantly higher than the latter (P<0.01).

CONCLUSION: TAP examination can be used to detect urothelial carcinoma of the bladder, and would be helpful in the diagnosis of urothelial carcinoma of the bladder by combining the clinical signs and symptoms.

Keywords: Bladder; glycoprotein; tumor abnormal protein; urothelial carcinoma

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