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Frangville C, Gallois M, Li Y, et al. Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity. Nanoscale. 2016;8(7):4252-9doi: 10.1039/c5nr05064b.
Frangville, C., Gallois, M., Li, Y., Nguyen, H. H., Lauth-de Viguerie, N., Talham, D. R., Mingotaud, C., & Marty, J. D. (2016). Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity. Nanoscale, 8(7), 4252-9. https://doi.org/10.1039/c5nr05064b
Frangville, Camille, et al. "Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity." Nanoscale vol. 8,7 (2016): 4252-9. doi: https://doi.org/10.1039/c5nr05064b
Frangville C, Gallois M, Li Y, Nguyen HH, Lauth-de Viguerie N, Talham DR, Mingotaud C, Marty JD. Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity. Nanoscale. 2016 Feb 21;8(7):4252-9. doi: 10.1039/c5nr05064b. PMID: 26837663.
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Nanoscale. 2016 Feb 21;8(7):4252-9. doi: 10.1039/c5nr05064b.

Hyperbranched polymer mediated size-controlled synthesis of gadolinium phosphate nanoparticles: colloidal properties and particle size-dependence on MRI relaxivity.

Nanoscale

Camille Frangville, Maylis Gallois, Yichen Li, Hong Hanh Nguyen, Nancy Lauth-de Viguerie, Daniel R Talham, Christophe Mingotaud, Jean-Daniel Marty

Affiliations

  1. Laboratoire IMRCP, Université de Toulouse, CNRS UMR 5623, UPS, 31062 Toulouse, France. [email protected].
  2. Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. [email protected].

PMID: 26837663 DOI: 10.1039/c5nr05064b

Abstract

Hyperbranched polymers based on the poly(amidoamine), HyPAM, were used to synthesize gadolinium phosphate nanowires under mild conditions. Control of the average particle size was obtained by adjusting polymer concentration. Proton relaxivity measurements reveal an optimum particle size, reaching relaxivity values as high as 55 ± 9 mM(-1) s(-1) for r1 and 67 ± 11 mM(-1) s(-1) for r2. The colloidal stability of these hybrid systems were optimized through the use of functionalized core-shell polymers containing PEG segments and C18-PEG segments, structures which also offer the possibility of imparting additional function into the polymer-particle hybrids.

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