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Martin DT, Schreiber MA. Modern resuscitation of hemorrhagic shock: what is on the horizon?. Eur J Trauma Emerg Surg. 2014;40(6):641-56doi: 10.1007/s00068-014-0416-5.
Martin, D. T., & Schreiber, M. A. (2014). Modern resuscitation of hemorrhagic shock: what is on the horizon?. European journal of trauma and emergency surgery : official publication of the European Trauma Society, 40(6), 641-56. https://doi.org/10.1007/s00068-014-0416-5
Martin, D T, and Schreiber, M A. "Modern resuscitation of hemorrhagic shock: what is on the horizon?." European journal of trauma and emergency surgery : official publication of the European Trauma Society vol. 40,6 (2014): 641-56. doi: https://doi.org/10.1007/s00068-014-0416-5
Martin DT, Schreiber MA. Modern resuscitation of hemorrhagic shock: what is on the horizon?. Eur J Trauma Emerg Surg. 2014 Dec;40(6):641-56. doi: 10.1007/s00068-014-0416-5. Epub 2014 Jun 17. PMID: 26814779.
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Eur J Trauma Emerg Surg. 2014 Dec;40(6):641-56. doi: 10.1007/s00068-014-0416-5. Epub 2014 Jun 17.

Modern resuscitation of hemorrhagic shock: what is on the horizon?.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

D T Martin, M A Schreiber

Affiliations

  1. Division of Trauma, Critical Care, and Acute Care Surgery, Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L-611, Portland, OR, 97239, USA. [email protected].
  2. Division of Trauma, Critical Care, and Acute Care Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L-611, Portland, OR, 97239, USA. [email protected].
  3. Division of Trauma, Critical Care, and Acute Care Surgery, Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L-611, Portland, OR, 97239, USA. [email protected].
  4. Division of Trauma, Critical Care, and Acute Care Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L-611, Portland, OR, 97239, USA. [email protected].

PMID: 26814779 DOI: 10.1007/s00068-014-0416-5

Abstract

PURPOSE: Mortality rates among the severely injured remain high. The successful treatment of hemorrhagic shock relies on expeditious control of bleeding through surgical ligation, packing, or endovascular techniques. An important secondary concern in hemorrhaging patients is how to respond to the lost blood volume. A single method that is able to adequately address all needs of the exsanguinating patient has not yet been agreed upon, despite a large growth of knowledge regarding the causative factors of traumatic shock.

METHODS: A review of relevent literature was performed.

CONCLUSIONS: Many different trials are currently underway to discriminate ways to improve outcomes in the severely injured and bleeding patient.  This paper will review: (1) recent advances in our understanding of the effects hemorrhagic shock has on the coagulation cascade and vascular endothelium, (2) recent research findings that have changed resuscitation, and (3) resuscitation strategies that are not widely used but under active investigation.

Keywords: FFP; Glycocalyx; Hemorrhagic shock; Resuscitation; Trauma; Trauma-induced coagulopathy

References

  1. Exp Physiol. 1991 Nov;76(6):825-57 - PubMed
  2. N Engl J Med. 1994 Oct 27;331(17):1105-9 - PubMed
  3. J Trauma. 2008 Mar;64(3):629-38; discussion 638-40 - PubMed
  4. J Trauma. 2007 Apr;62(4):868-79 - PubMed
  5. J Trauma Acute Care Surg. 2013 Oct;75(4):620-8 - PubMed
  6. Injury. 2013 Feb;44(2):209-16 - PubMed
  7. Crit Care Med. 2003 Apr;31(4):1160-5 - PubMed
  8. Surgery. 2013 Aug;154(2):388-96 - PubMed
  9. Transfusion. 2013 Jan;53 Suppl 1:65S-71S - PubMed
  10. Crit Care Med. 2013 May;41(5):1175-85 - PubMed
  11. Crit Care. 2013 Apr 19;17(2):R76 - PubMed
  12. J Trauma. 2008 Jan;64(1):9-14 - PubMed
  13. Arch Surg. 2012 Feb;147(2):113-9 - PubMed
  14. Semin Hematol. 2013 Jul;50(3):259-69 - PubMed
  15. Anesthesiology. 2003 Mar;98(3):699-704 - PubMed
  16. Cardiovasc Res. 2009 Jul 15;83(2):388-96 - PubMed
  17. Circulation. 2007 Oct 23;116(17):1896-906 - PubMed
  18. Shock. 2014 May;41 Suppl 1:70-5 - PubMed
  19. Annu Rev Biomed Eng. 2007;9:121-67 - PubMed
  20. J Trauma Acute Care Surg. 2012 Jul;73(1):60-6 - PubMed
  21. J Trauma. 2010 Aug;69(2):353-9 - PubMed
  22. J Cardiothorac Vasc Anesth. 2006 Apr;20(2):167-72 - PubMed
  23. J Trauma. 1995 Feb;38(2):185-93 - PubMed
  24. J Trauma. 2007 Oct;63(4):805-13 - PubMed
  25. J Immunol. 1998 Dec 1;161(11):6288-96 - PubMed
  26. J Trauma. 2008 Feb;64(2 Suppl):S79-85; discussion S85 - PubMed
  27. PLoS One. 2011;6(8):e23530 - PubMed
  28. Ann Surg. 2008 Sep;248(3):447-58 - PubMed
  29. J Trauma. 2010 Sep;69(3):489-500 - PubMed
  30. J Trauma. 2011 Mar;70(3):652-63 - PubMed
  31. Pflugers Arch. 2007 Jun;454(3):345-59 - PubMed
  32. Microvasc Res. 1999 Nov;58(3):281-304 - PubMed
  33. J Trauma. 2011 Sep;71(3):565-70; discussion 570-2 - PubMed
  34. Injury. 2011 Jan;42(1):78-82 - PubMed
  35. J Trauma. 2009 Apr;66(4 Suppl):S69-76 - PubMed
  36. J Trauma Acute Care Surg. 2012 Dec;73(6):1461-70 - PubMed
  37. J Surg Res. 2013 Sep;184(1):533-40 - PubMed
  38. Arch Surg. 2009 Sep;144(9):829-34 - PubMed
  39. Ann Surg. 2007 May;245(5):812-8 - PubMed
  40. Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2 - PubMed
  41. Transfusion. 2010 Oct;50(10):2145-51 - PubMed
  42. Cochrane Database Syst Rev. 2013 Jul 23;(7):CD007594 - PubMed
  43. Ann Surg. 2011 Mar;253(3):431-41 - PubMed
  44. Curr Opin Crit Care. 2007 Dec;13(6):680-5 - PubMed
  45. Shock. 2014 May;41 Suppl 1:35-8 - PubMed
  46. Injury. 2007 Mar;38(3):298-304 - PubMed
  47. Subcell Biochem. 2012;56:67-83 - PubMed
  48. Br J Anaesth. 2009 Feb;102(2):221-6 - PubMed
  49. Hamostaseologie. 2012;32(1):22-7 - PubMed
  50. J Trauma. 2008 Nov;65(5):986-93 - PubMed
  51. Anesthesiology. 2007 Nov;107(5):776-84 - PubMed
  52. Ann Surg. 2013 Oct;258(4):527-32; discussion 532-3 - PubMed
  53. Transfusion. 2013 Jan;53 Suppl 1:72S-79S - PubMed
  54. Med Hypotheses. 2010 Dec;75(6):564-7 - PubMed
  55. Transfusion. 2011 Feb;51(2):242-52 - PubMed
  56. Basic Res Cardiol. 2009 Jan;104(1):78-89 - PubMed
  57. Cochrane Database Syst Rev. 2012 Dec 12;12 :CD004388 - PubMed
  58. Cardiovasc Res. 2010 Jul 15;87(2):300-10 - PubMed
  59. JAMA Surg. 2013 Feb;148(2):127-36 - PubMed
  60. Lancet. 2010 Jul 3;376(9734):23-32 - PubMed
  61. J Biomed Biotechnol. 2011;2011:523481 - PubMed
  62. Nat Rev Genet. 2009 Jan;10(1):32-42 - PubMed
  63. Transfusion. 2013 Jan;53 Suppl 1:80S-90S - PubMed
  64. Shock. 2014 May;41 Suppl 1:62-9 - PubMed
  65. Crit Care. 2011;15(2):R83 - PubMed
  66. Arch Surg. 1991 Sep;126(9):1065-72 - PubMed
  67. J Trauma. 2002 Jun;52(6):1141-6 - PubMed
  68. Crit Care. 2011;15(6):R272 - PubMed
  69. Ann Biomed Eng. 2012 Apr;40(4):840-8 - PubMed
  70. J Trauma Acute Care Surg. 2013 Jul;75(1 Suppl 1):S24-30 - PubMed
  71. J Trauma Acute Care Surg. 2012 Aug;73(2 Suppl 1):S49-53 - PubMed
  72. Crit Care. 2008;12(4):R105 - PubMed
  73. J Am Coll Surg. 2010 Jun;210(6):957-65 - PubMed
  74. J Trauma. 2011 Dec;71(6):1761-4; discussion 1764-5 - PubMed
  75. Surgery. 2009 Aug;146(2):325-33 - PubMed
  76. Br J Anaesth. 1999 Apr;82(4):510-5 - PubMed
  77. J Trauma. 2010 Jul;69 Suppl 1:S55-63 - PubMed
  78. J Trauma Acute Care Surg. 2013 Jul;75(1 Suppl 1):S40-7 - PubMed
  79. JPEN J Parenter Enteral Nutr. 2008 Jul-Aug;32(4):384-8 - PubMed
  80. J Trauma Acute Care Surg. 2013 Dec;75(6):1031-9 - PubMed
  81. J Surg Res. 2012 Nov;178(1):321-9 - PubMed
  82. World J Surg. 2010 Jan;34(1):158-63 - PubMed
  83. Ann Surg. 2010 Sep;252(3):434-42; discussion 443-4 - PubMed
  84. Circulation. 1999 Jul 20;100(3):226-9 - PubMed
  85. Arch Surg. 2000 Mar;135(3):326-31 - PubMed
  86. Br J Anaesth. 2011 Nov;107(5):693-702 - PubMed
  87. J Thromb Haemost. 2012 Jul;10(7):1342-51 - PubMed
  88. Shock. 2013 Dec;40(6):444-50 - PubMed
  89. Shock. 2007 Dec;28(6):644-649 - PubMed
  90. Ann Biomed Eng. 1998 Jul-Aug;26(4):627-43 - PubMed
  91. J Trauma. 2011 Jul;71(1):20-4; discussion 24-5 - PubMed
  92. Transfusion. 2013 Jan;53 Suppl 1:107S-113S - PubMed
  93. J Trauma. 2003 Jun;54(6):1127-30 - PubMed
  94. Am J Clin Nutr. 1996 May;63(5):760-5 - PubMed
  95. Ann Surg. 2011 Aug;254(2):194-200 - PubMed
  96. J Exp Med. 2011 Dec 19;208(13):2581-90 - PubMed
  97. Blood. 2011 Aug 18;118(7):1943-51 - PubMed
  98. J Physiol. 2004 Jun 15;557(Pt 3):889-907 - PubMed
  99. J Trauma Acute Care Surg. 2014 Jan;76(1):12-9; discussion 19-20 - PubMed
  100. J Vasc Surg. 2012 Apr;55(4):1096-1103.e51 - PubMed
  101. J Trauma. 2006 Jul;61(1):181-4 - PubMed
  102. Br J Anaesth. 2011 Sep;107(3):378-87 - PubMed
  103. Exp Physiol. 1997 Jan;82(1):1-30 - PubMed
  104. Microvasc Res. 2013 Jan;85:128-33 - PubMed
  105. Clin Pharmacokinet. 2012 Apr 1;51(4):225-36 - PubMed
  106. FASEB J. 2008 Oct;22(10):3549-60 - PubMed
  107. World J Surg. 2011 Feb;35(2):430-9 - PubMed
  108. Blood Transfus. 2013 Oct;11(4):500-5 - PubMed
  109. Crit Care. 2004 Feb;8(1):15-23 - PubMed
  110. Anesth Analg. 2011 Feb;112(2):395-404 - PubMed
  111. Injury. 2012 Jan;43(1):26-32 - PubMed
  112. J Surg Res. 2014 Jan;186(1):363-70 - PubMed
  113. Crit Care. 2003 Dec;7(6):427-34 - PubMed
  114. Anesth Analg. 2011 Jun;112(6):1289-95 - PubMed
  115. Crit Care. 2007;11(4):R81 - PubMed
  116. JAMA. 2010 Oct 6;304(13):1455-64 - PubMed
  117. Transfus Apher Sci. 2006 Jun;34(3):289-98 - PubMed
  118. J Am Coll Surg. 2010 May;210(5):870-80, 880-2 - PubMed
  119. Ann Surg. 2002 Dec;236(6):814-22 - PubMed

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