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Attari Z, Bhandari A, Jagadish PC, et al. Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology. Saudi Pharm J. 2015;24(1):57-63doi: 10.1016/j.jsps.2015.03.008.
Attari, Z., Bhandari, A., Jagadish, P. C., & Lewis, S. (2016). Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 24(1), 57-63. https://doi.org/10.1016/j.jsps.2015.03.008
Attari, Zenab, et al. "Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 24,1 (2016): 57-63. doi: https://doi.org/10.1016/j.jsps.2015.03.008
Attari Z, Bhandari A, Jagadish PC, Lewis S. Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology. Saudi Pharm J. 2016 Jan;24(1):57-63. doi: 10.1016/j.jsps.2015.03.008. Epub 2015 Mar 20. PMID: 26903769; PMCID: PMC4720021.
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Saudi Pharm J. 2016 Jan;24(1):57-63. doi: 10.1016/j.jsps.2015.03.008. Epub 2015 Mar 20.

Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Zenab Attari, Amita Bhandari, P C Jagadish, Shaila Lewis

Affiliations

  1. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.
  2. Department of Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.

PMID: 26903769 PMCID: PMC4720021 DOI: 10.1016/j.jsps.2015.03.008

Abstract

The purpose of this study was to develop nanosuspension based on combinative technology to enhance the intestinal absorption of Olmesartan medoxomil (OLM), a potent antihypertensive agent with limited oral bioavailability. Two combinative approaches were employed and then characterized. In vitro intestinal absorption of OLM nanosuspension and plain OLM was studied using non-everted rat intestinal sac model. Optimal OLM nanosuspension was prepared by a combination of ball milling and probe sonication using stabilizer, Poloxamer 407. The formula exhibited particle size of 469.9 nm and zeta potential of -19.1 mV, which was subjected to ex vivo studies. The flux and apparent permeability coefficient in intestine from OLM nanosuspension was higher than the plain drug, thereby suggesting better drug delivery.

Keywords: Combination methods; HPH, high pressure homogenization; Intestinal absorption; Nanosuspension; OLM, olmesartan medoxomil; P407, Poloxamer 407; PDI, polydispersity index; Particle size

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